Results 121 to 130 of about 46,296 (214)

Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

Molecular Cancer, 2019
Background Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contributes to development of ...
Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun, Chuanxin Wang   +12 more
doaj   +1 more source

DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer

Oncogenesis
Oxaliplatin is effective against colorectal cancer (CRC), but resistance hampers treatment. We found upregulated Dickkopf-1 (DKK1, a secreted protein) in oxaliplatin-resistant (OR) CRC cell lines and DKK1 levels increased by more than 2-fold in ...
Chi-Che Hsieh, Ting-Wei Li, Chun-Chun Li, Shang-Hung Chen, You-Lin Wei, Nai-Jung Chiang, Che-Hung Shen   +6 more
doaj   +1 more source

OCT2 demethylation cracks open oxaliplatin resistance [PDF]

Nature Reviews Nephrology, 2016
openaire   +1 more source

Isolation and characterisation of putative colorectal cancer stem cells

, 2010
The isolation and characterisation of cancer stem cells (CSCs) remain a major challenge. The ‘traditional’ (or ‘stochastic’) model of cancer suggests that cancer cells progress through clonal evolution and therefore, all cancer cells must be destroyed.
du Potet, Elodie, du Potet, Elodie
core   +1 more source

A Novel Modulator of Resistance for Oxaliplatin-Based Therapy for Colorectal Cancer: The ESCRT Family Member VPS4A

Cells
Drug resistance is still one of the main challenges for the treatment of colorectal cancer (CRC). Whilst some resistance mechanisms are well known, from the static therapy success rate, clearly, still much is undiscovered.
Noha M. Abdelrazik, Anjana Patel, Andrew Conn, Christopher W. Sutton, Sriharsha Kantamneni, Steven D. Shnyder   +5 more
doaj   +1 more source

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer.
Brody, Jonathan, Campbell, Paul M., Chand, Saswati N., Cheung, Edwin C,, Dixon, Dan A., Goetz, Austin, Lal, Shruti, Londin, Eric, Lowder, Cinthya Y., Mambelli-Lisboa, Nicole C., Nevler, Avinoam, Preet, Ranjan, Romeo, Carmella, Stout, Matthew C., Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +16 more
core   +1 more source

Engineering a nano delivery system targets EphA2 for treating colorectal cancer oxaliplatin resistant

Materials & Design
As a first-line chemotherapeutic regimen, oxaliplatin resistance is a challenge for colorectal cancer treatment. Eph receptor A2 (EphA2) is highly expressed in colorectal tumors and is an important contributor to the poor prognosis of the patients ...
Zhengshuo Li, Xiaoyue Zhang, Can Liu, Yangge Wu, Yuqing Wen, Run Zheng, Chenxiao Xu, Junrui Tian, Qiu Peng, Xiang Zheng, Jia Wang, Lingyu Wei, Qun Yan, Jian Ma   +13 more
doaj   +1 more source

Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors [PDF]

, 2017
The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC
Brody, Jonathan R., Chand, Saswati N., Cozzitorto, Joseph A., Jiang, Wei, Knudsen, Karen E., Lal, Shruti, Londin, Eric R., Meisner-Kober, Nicole, Nevler, Avinoam, Pascal, John M, Pishvaian, Michael J., Romeo, Carmella, Sanan, Akshay R., Schiewer, M. J., Scolaro, Laura, Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +17 more
core   +1 more source

Gene expression profiling of oxaliplatin-resistant cell lines [PDF]

Nature Genetics, 2001
Goli Samimi, Jim Breaux, Misako Mishima, Charles Berry, Stephen Howell, Gerrit Los   +5 more
openaire   +1 more source

ΔNp73 overexpression induces oxaliplatin-resistance in colon cancer

, 2015
Resumen del póster presentado al 2nd Symposium on Biomedical Research: "Advances and perspectives in cancer", celebrado en Madrid el 17 de abril de 2015.-- et al. [Background]: Aberrant expression of ΔNp73 has been associated with shorten cancer patient survival.
Bonilla, Félix, Domínguez, Gemma
openaire   +1 more source