Results 161 to 170 of about 3,144,476 (264)

Decoding Senescence‐Driven Heterogeneity in Early‐Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Cancer Science, EarlyView.
We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai, Mingru Mai, Rende Huang, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu, Yize Mao, Zihuan Yang, Feng Gao   +11 more
wiley   +1 more source

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

OCT2 demethylation cracks open oxaliplatin resistance [PDF]

Nature Reviews Nephrology, 2016
openaire   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, EarlyView.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

A Novel Modulator of Resistance for Oxaliplatin-Based Therapy for Colorectal Cancer: The ESCRT Family Member VPS4A

Cells
Drug resistance is still one of the main challenges for the treatment of colorectal cancer (CRC). Whilst some resistance mechanisms are well known, from the static therapy success rate, clearly, still much is undiscovered.
Noha M. Abdelrazik, Anjana Patel, Andrew Conn, Christopher W. Sutton, Sriharsha Kantamneni, Steven D. Shnyder   +5 more
doaj   +1 more source

Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights

, 2016
There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve functional tumour-associated blood vessel deterioration and normalisation. The former aims
Alfonso, J. C. L., Deutsch, A., Feuerhake, F., Hatzikirou, H., Kohn-Luque, A., Stylianopoulos, T.   +5 more
core   +1 more source

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer.
Brody, Jonathan, Campbell, Paul M., Chand, Saswati N., Cheung, Edwin C,, Dixon, Dan A., Goetz, Austin, Lal, Shruti, Londin, Eric, Lowder, Cinthya Y., Mambelli-Lisboa, Nicole C., Nevler, Avinoam, Preet, Ranjan, Romeo, Carmella, Stout, Matthew C., Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +16 more
core   +1 more source

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source

Engineering a nano delivery system targets EphA2 for treating colorectal cancer oxaliplatin resistant

Materials & Design
As a first-line chemotherapeutic regimen, oxaliplatin resistance is a challenge for colorectal cancer treatment. Eph receptor A2 (EphA2) is highly expressed in colorectal tumors and is an important contributor to the poor prognosis of the patients ...
Zhengshuo Li, Xiaoyue Zhang, Can Liu, Yangge Wu, Yuqing Wen, Run Zheng, Chenxiao Xu, Junrui Tian, Qiu Peng, Xiang Zheng, Jia Wang, Lingyu Wei, Qun Yan, Jian Ma   +13 more
doaj   +1 more source