Results 181 to 190 of about 46,296 (214)
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Altered glutathione metabolism in oxaliplatin resistant ovarian carcinoma cells
Cancer Letters, 1996Elevation of glutathione (GSH) is commonly observed in cellular resistance to a number of anticancer agents. Most frequently reported change in GSH metabolism that is associated with the elevated GSH levels is increased mRNA expression and activity of gamma-glutamyl cysteine synthetase (gamma GCS), the first enzyme of the GSH biosynthetic pathway.
Z, el-akawi +6 more
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In vitro studies on the mechanisms of oxaliplatin resistance
Cancer Chemotherapy and Pharmacology, 2001We have previously reported that elevation of glutathione mediated by gamma-glutamyl transpeptidase is one mechanism of oxaliplatin resistance. This study explored other potential oxaliplatin resistance mechanisms with two aims: (1) to identify the differences between cisplatin and oxaliplatin in terms of drug accumulation, DNA-Pt adduct formation and ...
S, Hector +4 more
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Clinical Cancer Research, 2007
AbstractPurpose: To establish whether cetuximab, a chimeric IgG1 antibody targeting epidermal growth factor receptor, has the potential to restore responsiveness to oxaliplatin in preclinical cancer models, as has been shown with irinotecan in irinotecan refractory metastatic colorectal cancer patients.Experimental Design: The effects of cetuximab and ...
Marie, Prewett +6 more
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AbstractPurpose: To establish whether cetuximab, a chimeric IgG1 antibody targeting epidermal growth factor receptor, has the potential to restore responsiveness to oxaliplatin in preclinical cancer models, as has been shown with irinotecan in irinotecan refractory metastatic colorectal cancer patients.Experimental Design: The effects of cetuximab and ...
Marie, Prewett +6 more
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High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance
Apoptosis, 2023Pyroptosis, as a type of inflammatory programmed cell death, has been studied in inflammatory diseases and numerous cancers but its role in pancreatic ductal adenocarcinoma (PDAC) remains further exploration.A TCGA-PDAC cohort was enrolled for bioinformatics analysis to investigate the effect of pyroptosis on the prognosis and drug sensitivity of ...
Guangfu, Wang +8 more
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Txr1: an important factor in oxaliplatin resistance in gastric cancer
Medical Oncology, 2013Oxaliplatin-based chemotherapy is the main treatment regimen for gastric cancer (GC), but can fail because of drug resistance. We investigated the role of a recently identified drug-resistance gene, taxol-resistant gene 1 (Txr1), in oxaliplatin resistance. A retrospective study based on banked tissue was carried out.
Jingtao, Bi +8 more
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Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
Archives of Pharmacal Research, 2021Resolution to chemoresistance is a major challenge in patients with advanced-stage malignancies. Thus, identification of action points and elucidation of molecular mechanisms for chemoresist human cancer are necessary to overcome this challenge. In this study, we provide important evidence that kaempferol targeting RSKs might be a strategy to reduce ...
Juhee Park +11 more
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Cellular Resistance to Oxaliplatin and Drug Accumulation Defects
2009Platinum drugs are employed in a wide range of solid tumors, and represent the mainstay of the first-line therapy of ovarian carcinoma. Although cisplatin has shown efficacy in the treatment of different types of tumors including ovarian carcinoma, resistance to treatment is a major limitation.
Laura Gatti, Paola Perego
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Polyene phosphatidylcholine overcomes oxaliplatin resistance in human gastric cancer BGC823 cells
Biochemical and Biophysical Research Communications, 2018Intrinsic or acquired resistance to oxaliplatin (L-OHP) is a major reason of treatment failure in gastric cancer and limits therapeutic success. Here we generated an oxaliplatin resistant gastric cancer cell line, BGC823/L-OHP, to investigate the effect of a hepatoprotective compound, polyene phosphatidylcholine (PPC), on conquest of oxaliplatin ...
Hongjun, Zhang +6 more
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Role of Dicer in regulating oxaliplatin resistance of colon cancer cells
Biochemical and Biophysical Research Communications, 2018Colorectal cancer (CRC) is a major health problem due to its high mortality rate. The incidence of CRC is increasing in young individuals. Oxaliplatin (OXA) is an approved third-generation drug and is used for first-line chemotherapy in CRC. Although current standard chemotherapy improves the overall survival of CRC patients, an increasing number of ...
Hui-Huang Lai +3 more
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Abstract 4559: SMAD3 mediates oxaliplatin resistance in esophageal adenocarcinoma
Cancer ResearchAbstract Background: Resistance to conventional treatments is a significant barrier to esophageal adenocarcinoma (EAC) therapy. TGF-β signaling appears to be important for EAC tumorigenesis; however, its role in EAC chemoresistance remains understudied.
Farah Ballout +8 more
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