Results 81 to 90 of about 18,651 (251)

Multicomponent Assembly of Proposed DNA Precursors in Water [PDF]

, 2012
We propose a novel pathway for the prebiotic synthesis of 2′-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic amino acids, serine and ...
Powner, Matthew W., Szostak, Jack William, Zheng, Shao-Liang   +2 more
core   +1 more source

Biosynthese der Biphenomycine, einer Familie potenter Antibiotika

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
Der vollständige Biosyntheseweg der Biphenomycin‐Antibiotika wird aufgeklärt und offenbart eine einzigartige enzymatische Maschinerie mit einem bifunktionellen MNIO, einer regioselektiven Arginase, einem B12‐abhängigen rSAM für C,C‐Kupplung, Enzymen zur Hydroxylierung sowie einer zweifach spezifischen Metalloprotease.
Elisabeth Strunk, Alfred Lobert, Tatiana Khorovich, Katia M. Guzman Lucio, René Richarz, Maximilian Hohmann, Paul M. D'Agostino, Tobias A. M. Gulder   +7 more
wiley   +1 more source

Crystal structure of 3-benzylsulfanyl-6-(5-methyl-1,2-oxazol-3-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C14H11N5OS2, the triazolo–thiadiazole system is essentially planar (r.m.s. deviation = 0.002 Å) and makes dihedral angles of 6.33 (12) and 42.95 (14)° with the planes of the oxazole and phenyl rings, respectively.
Krishnaiah Vaarla, V. Rajeswar Rao, Mehmet Akkurt   +2 more
doaj   +1 more source

Sir John Cornforth AC CBE FRS: his synthetic work [PDF]

, 2015
Sir John Cornforth’s work on the synthesis of cholesterol and penicillamine, on the chemistry of oxazoles, the stereochemistry of the synthesis of alkenes, the synthesis of abscisic acid and of dibenzophospholes as mimics of enzyme action, is ...
Abraham E.P., Abraham E.P., Abraham E.P., Callow R.K., Cardwell H.M.E., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., James R. Hanson, Rupert Purchase   +15 more
core   +1 more source

Biosynthesis of the Biphenomycin Family of Potent Antibiotics

Angewandte Chemie International Edition, Volume 64, Issue 51, December 15, 2025.
The complete biosynthetic pathway of the biphenomycin antibiotics is elucidated, revealing a unique enzymatic machinery featuring a bifunctional MNIO, a regioselective arginase, a B12‐dependent rSAM for C,C coupling, hydroxylation enzymology, and a metalloprotease with dual‐specificity.
Elisabeth Strunk, Alfred Lobert, Tatiana Khorovich, Katia M. Guzman Lucio, René Richarz, Maximilian Hohmann, Paul M. D'Agostino, Tobias A. M. Gulder   +7 more
wiley   +1 more source

A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins

, 2015
Bacteriocins are peptide-derived molecules produced by bacteria, whose recently-discovered functions include virulence factors and signalling molecules as well as their better known roles as antibiotics.
Freed, Stefan D, Friedberg, Iddo, Lee, Shaun W, Morton, James T   +3 more
core   +1 more source

One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds [PDF]

, 2014
One-pot multi-reaction processes involving Overman rearrangements, metathesis cyclizations, and Diels–Alder reactions have been developed for the rapid and efficient synthesis of amino-substituted carbocyclic and heterocyclic compounds.
Calder, Ewen D.D., Grafton, Mark W., Sutherland, Andrew   +2 more
core   +1 more source

Total Synthesis of Bacterial 5-(3-Indolyl)oxazole Alkaloids: Pimprinols A–C

SynOpen, 2019
Pimprinols A, B, and C are bacterial 5-(3-indolyl)oxazole alkaloids that have been isolated from Streptomyces sp. Lv3–13. In this paper, we report a new synthesis of pimprinol A and the first total synthesis of pimprinol B and pimprinol C.
Tímea Szabó, Róbert Kormány, András Dancsó, Balázs Volk, Mátyás Milen   +4 more
doaj   +1 more source

Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes [PDF]

, 2008
peer-reviewedStreptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal
Casey, Patrick G., Cotter, Paul D., Daly, Karen M., Draper, Lorraine A., Groeger, David S., Hill, Colin, Lawton, Elaine M., Ross, R Paul   +7 more
core   +4 more sources

Synthesis of Novel BINOL Analogs: 3,3′‐Dicarbonyl‐1,1′‐binaphthyl‐4,4′‐diols as Precursors to the Uncharted 5,5′‐Binaphtho[2,1‐d]isoxazole

European Journal of Organic Chemistry, Volume 28, Issue 45, December 10, 2025.
The parent 5,5′‐binaphtho[2,1‐d]isoxazole and its 3,3′‐dimethyl and 3,3′‐diphenyl derivatives are synthesized via condensation of the respective dicarbonyl compounds with hydroxylamine, followed by cyclodehydration of the resulting dioximes. The dicarbonyl precursors are obtained through 4‐ or 6‐step sequences from 1‐naphthol or 1‐naphthaldehyde ...
Marek Surowiec, Ioannis E. Gerontitis, Petros G. Tsoungas, Panteleimon G. Takis, Panagiotis Stathopoulos, Erietta Pouliou, George Varvounis   +6 more
wiley   +1 more source