A new oxazolidinone antimicrobial [PDF]
American Journal of Health-System Pharmacy, 2014 Purpose. The mechanism of action, pharmacokinetics, pharmacodynamics, and clinical efficacy and safety of an investigational second-generation oxazolidinone are reviewed. Summary. Tedizolid is a protein synthesis inhibitor in clinical development for the
Childs, Lindsay M, +3 more
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Combination of a UPO-Based Epoxidation With a Subsequent Ring-Opening Reaction for the Synthesis of Amino Alcohols. [PDF]
ChembiochemThe synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Last S +3 more
europepmc +2 more sources
An in vitro evaluation of the efficacy of tedizolid: implications for the treatment of skin and soft tissue infections [PDF]
, 2018 Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide.
Aleryan, Muna +4 more
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Antibiotics, 2022 The increasing number of nosocomial pathogens with resistances towards last resort antibiotics, like linezolid for gram positive bacteria, leads to a pressing need for screening and, consequently, suitable screening media.
Delphine Girlich +7 more
doaj +1 more source
Bacterial resistance to antimicrobial agents and its impact on veterinary and human medicine [PDF]
, 2016 Background Antimicrobial resistance has become a major challenge in veterinary medicine, particularly in the context of bacterial pathogens that play a role in both humans and animals.
Aarestrup +123 more
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Microwave accelerated efficient synthesis of N-fluorenylmethoxycarbonyl/t-butoxycarbonyl/benzyloxycarbonyl-5- oxazolidinones [PDF]
, 2002 The synthesis of N-protected 5-oxazolidinones using amino acids, paraformaldehyde and p-toluene sulfonic acid in a minimum amount of toluene accelerated by microwave irradiation for 3 min in high yield is described. © 2002 Elsevier Science Ltd.
Kantharaju, . +2 more
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Molecules, 2008 Two recently synthesized oxazolidinones: (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (DA-7157) and itscorresponding pro-drug (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-2-oxo-5 ...
Lucio Vera-Cabrera +8 more
doaj +1 more source
Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
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Synthesis and Characterization of Novel Oxazolidinones Via Schiff Base Reactions [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2013 A number of new novel 2,3-disubstituted-1,3-oxazolidine-5-one derivatives were synthesized by the reaction of Schiff‘s bases with chloroacetic acid in dry banzene with high yields. Schiff bases were synthesized by the reaction of heteroaromatic aldehydes
Obaid H.Abid, Aws K. Mohamed
doaj +1 more source
Synthesis of novel urethanes from a castor oil derived C22-acyloin [PDF]
, 2011 The synthesis of new bio-based chemical building blocks, resulting from the condensation of a renewable C-22 acyloin derived from non-edible castor oil, with mono- and bifunctional isocyanates is reported. The condensation with aliphatic mono-isocyanates
Stevens, Christian +2 more
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