Results 31 to 40 of about 10,637 (203)

Coexistence of the Oxazolidinone Resistance–Associated Genes cfr and optrA in Enterococcus faecalis From a Healthy Piglet in Brazil

Frontiers in Public Health, 2020
Oxazolidinones are one of the most important antimicrobials potentially active against glycopeptide- and β-lactam-resistant Gram-positive pathogens.
Lara M. Almeida, Lara M. Almeida, Anthony Gaca, Paulo M. Bispo, François Lebreton, Jose T. Saavedra, Rafael A. Silva, Irinaldo D. Basílio-Júnior, Felipe M. Zorzi, Pedro H. Filsner, Andrea M. Moreno, Michael S. Gilmore   +11 more
doaj   +1 more source

Comparative study of in vitro activity of tedizolid and linezolid against Mycobacterium avium complex.

Journal of Global Antimicrobial Resistance, 2022
Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a ...
Eduardo Marfil, Pilar Ruiz, Luis Martínez-Martínez, Manuel Causse   +3 more
doaj   +1 more source

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

Pharmaceutics, 2011
Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity.
Jan-Willem C. Alffenaar, Arianna D. Pranger, Mathieu S. Bolhuis, Jos G. W. Kosterink, Prashant N. Panday   +4 more
doaj   +1 more source

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides [PDF]

, 2015
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route.
Ali Alhalib, Bode H. B., Degnan B. M., Dohi T., Dohi T., Fujita M., Fujita M., Guilbault A.-A., Guilbault A.-A., Hamnett D. J., Kong A., Mizar P., Moon N. G., Murai T., Ngatimin M., Parra A., Richardson R. D., Rodríguez A., Rodríguez A., Shimogaki M., Somaia Kamouka, Suzuki S., Uyanik M., Uyanik M., Wesley J. Moran, Wu H., Yan J., Zhdankin V. V., Zheng Z. S., Zhong W., Zhou Z.-S.   +30 more
core   +1 more source

Carbon dioxide-based facile synthesis of cyclic carbamates from amino alcohols [PDF]

, 2018
We report herein a straightforward general method for the synthesis of cyclic carbamates from amino alcohols and carbon dioxide in the presence of an external base and a hydroxyl group activating reagent.
Fernández, Israel, Mannisto, Jere Kristian, Niemi, Teemu Yrjö Manuel, Repo, Timo Juhani, Steadman, Bethany   +4 more
core   +1 more source

Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]

, 2010
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique, De Bus, Liesbet, Depuydt, Pieter, Libbrecht, Louis, NOLLET, JOKE, Van Vlierberghe, Hans, Vandekerckhove, Linos, Vogelaers, Dirk   +7 more
core   +1 more source

Cu(I)/Ionic Liquids Promote the Conversion of Carbon Dioxide into Oxazolidinones at Room Temperature

Molecules, 2019
Recently, the efficient chemical fixation of carbon dioxide (CO2) into high value chemicals without using noble metal catalysts has become extremely appealing from the viewpoint of sustainable chemistry.
Jikuan Qiu, Yue Zhao, Yuling Zhao, Huiyong Wang, Zhiyong Li, Jianji Wang, Tiantian Jiao   +6 more
doaj   +1 more source

Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China

International Journal of Infectious Diseases, 2021
Background: The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful.
Shu’an Wen, Xiaopan Gao, Weijie Zhao, Fengmin Huo, Guanglu Jiang, Lingling Dong, Liping Zhao, Fen Wang, Xia Yu, Hairong Huang   +9 more
doaj   +1 more source

Analysis of combined resistance to oxazolidinones and phenicols among bacteria from dogs fed with raw meat/vegetables and the respective food items [PDF]

, 2019
The gene optrA is the first gene that confers resistance to the oxazolidinone tedizolid, a last resort antimicrobial agent in human medicine. In this study we investigated the presence of optrA and the multi-resistance genes poxtA and cfr in enterococci ...
Fan, Run, Feßler, Andrea T., Lei, Lei, Schwarz, Stefan, Wang, Yang, Wang, Yinchao, Wang, Zheng, Wu, Congming, Wu, Yifan   +8 more
core   +1 more source

Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]

, 2012
Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Long, Katherine S., Vester, Birte
core   +1 more source