Results 51 to 60 of about 10,637 (203)

Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017 [PDF]

, 2018
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms.
Aghdassi, S., Alberg, T., Arendt, V., Arvaniti, K., Asensio, A., Berg, T. C., Berger-Carbonne, A., Borg, M. A., Bosnjak, Z., Budimir, A., Burns, K., Cairns, S., Cantero, M., Daniau, C., Debacker, M., Deptula, A., Dimina, E., Dobreva, E., Dragovac, G., Florentin, D., Gastmeier, P., Gibbons, C., Gudlaugsson, O., Hadjihannas, L., Hajdu, A., Hansen, S., Harrison, W., Hopkins, S., Hopmans, T., Hristova, R., Ivanov, I. N., Jindrak, V., Johnson, A., Karki, T., Kinross, P., Kontopidou, F., Korosec, A., Latour, K., Litvova, S., Lyytikainen, O., Markovic-Denic, L., Martin, P., McConaghy, M., Mitt, P., Monnet, D. L., Moro, M. L., Nedyalkov, M., Neves, I., Niculcea, A. S., Pacheco, P., Plachouras, D., Presterl, E., Quattrocolo, F., Reilly, J., Rydygier, L., Sartaj, M., Sarvikivi, E., Serban, R. I., Smid, E., Staniulyte, J., Stefkovicova, M., Strauss, R., Suetens, C., Vandael, E., Vilde, A., Weist, K., Zarb, P., Zingg, W., Zotti, C. M., Zupanc, T. L.   +69 more
core   +7 more sources

Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐Bis‐Carbofunctionalization

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
A four‐component synthesis of azetidines with an all‐carbon quaternary center via strain‐release 1,3‐bis‐carbofunctionalization of 1‐azabicyclobutanes (ABB) is described. Each reaction component can be modified to permit a high‐throughput‐like library preparation, producing azetidines with various appendages, including biorelevant molecules.
Yi‐Hua Lee, Che‐Ming Hsu, Shinje Miñoza, Ya‐Fang Shih, Yu‐Chun Ding, Tzu‐Yao Hsu, Song‐Ting Chen, Kuei‐Chen Chang, Wen‐Hsuan Lee, Yuya A. Lin, Hsuan‐Hung Liao   +10 more
wiley   +2 more sources

Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis. [PDF]

, 2019
BACKGROUND:Drug-resistant fish pathogens can cause significant economic loss to fish farmers. Since 2012, florfenicol has become an approved drug for treating both septicemia and columnaris diseases in freshwater fish.
Liao, Chao, Terhune, Jeffery, Wang, Luxin, Zeng, Qifan   +3 more
core  

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Doxycycline alters metabolism and proliferation of human cell lines. [PDF]

, 2013
The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few ...
Ahler, Ethan, Bensinger, Steven J, Braas, Daniel, Cass, Ashley, Christofk, Heather R, Graeber, Thomas G, Sullivan, William J, York, Autumn G   +7 more
core   +3 more sources

Metal Nanoparticles on Halloysite Applied in Stereoselective Hydrogenation of Tetrasubstituted Alkenes

Chemistry – A European Journal, EarlyView.
Composite materials based on metal nanoparticles supported on a naturally occurring nanotubular clay, halloysite (HAL), led to the diastereoselective hydrogenation of tetra‐substituted alkenes under relatively smooth conditions, mainly oxazolidinone‐based heterocycles.
Rosa Pich, Gabriel Domínguez, Leo Westrey, Pierre Lavedan, Sonia Mallet‐Ladeira, Jérôme Esvan, Jean‐François Lahitte, Jean‐Christophe Remigy, Daniel Pla, Montserrat Gómez   +9 more
wiley   +1 more source

Cost-effectiveness of different MRSA screening methods.

, 2002
We describe a model to examine the cost-effectiveness of various laboratory-screening approaches to detect methicillin-resistant Staphylococcus aureus (MRSA).
Cookson, B, Kibbler, C, Kunori, T, Roberts, JA, Stone, S   +4 more
core   +1 more source

ChemInform Abstract: Synthesis of Urea Tethered Glycosylated Amino Acids and Glycopeptides Mediated by DPPA Employing Nα‐Fmoc‐Asp/Glu‐5‐oxazolidinones [PDF]

, 2009
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option ...
Hemantha, H.P., Nagendra, G., Sureshbabu, V.V.   +2 more
core   +1 more source

Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe

Chemistry – A European Journal, EarlyView.
The azomethine imine (AMI)–isonitrile (NC) ligation allowed for the chemoselective detection of natural isonitriles in bacteria and fungi. The reactivity‐based screening establishes a new stereogenic center, thereby allowing for facile distinction between chiral and achiral isonitriles. The work also unraveled a unique reactivity of isonitriles bearing
Maurice P. Biedermann, Alexander Brachmann, Shurui Mai, Athanasios Markos, Markus Künzler, Jörn Piel, Helma Wennemers   +6 more
wiley   +1 more source

Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects

Molecules, 2021
This review covers the main aspects concerning the chemistry, the biological activity and the analytical determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clinical use over the past 50 years.
Claudia Foti, Anna Piperno, Angela Scala, Ottavia Giuffrè   +3 more
doaj   +1 more source