Results 101 to 110 of about 747,150 (312)

DNA Damage and Oxidative Status of Full Term Babies Delivered by Spontaneous Vaginal Delivery and Caesarean Section

Gynecology Obstetrics & Reproductive Medicine, 2019
Objectives: At this study, it is aimed to research DNA damage and oxidative stress in infants with born timely normal spontaneous vaginal delivery (NSVD) and elective caesarean.
Halil Kazanasmaz, Mahmut Abuhandan
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Investigating the Hepatoprotective Properties of Mulberry Leaf Flavonoids against Oxidative Stress in HepG2 Cells

Molecules
Oxidative stress significantly contributes to ageing and disease, with antioxidants holding promise in mitigating its effects. Functional foods rich in flavonoids offer a potential strategy to mitigate oxidative damage by free radicals.
Qinhua Zheng, Ke Feng, Wenting Zhong, Weijian Tan, Sa Rengaowa, Wenzhong Hu   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Effect of Pomegranate Juice Supplementation on Oxidative Stress in Young Healthy Males [PDF]

Background & Objectives: The intake of antioxidant supplementations can have key role in prevention of oxidative stress in healthy individuals. Pomegranate has antioxidant effects and may play a role in reduction of oxidative stress in healthy males ...
نعمتی, علی, شادمان فرد, علی, مأذنی, محمد, نقی زاده باقی, عباس   +3 more
core  

Oxidative damage.

, 2006
3.1. Biomarkers of DNA base oxidation 3.2. Lipid peroxidation induced DNA damage Free radical attack upon DNA generates, among other changes, modified bases. The amount of 8-oxo-7,8-dihydroguanine, one of the most critical lesions in human lymphocytes, was found to be 1.2/106. Gua by a mass spectrometric approach.
Olinski, Ryszard, Loft, Steffen, Nair, Urmila, Nair, Jagadeesan   +3 more
openaire  

Melatonin ameliorates zearalenone-induced ovarian damage in mice through antioxidative effects

Frontiers in Veterinary Science
IntroductionZearalenone (ZEN), a mycotoxin from Fusarium species, is widely present in contaminated grains and animal products. It exerts estrogen-like effects, disrupting hormonal balance and reproductive function, partly through oxidative stress ...
Yi Song, Yi Song, Yi Song, Zhong Guo, Zhong Guo, Lei Song, Lei Song, Jianxiu Ma, Jianxiu Ma, Zhifang Zhao, Zhifang Zhao, Yanqing Ma, Xiaoyue Ma, Wenjie Jiang, Wanjing Wang, Chongran Liu, Tongtong Wei, Ling Fu, Zhengli Qi, Jin Zhao, Jin Zhao, Jin Zhao   +21 more
doaj   +1 more source

The CHD6 chromatin remodeler is an oxidative DNA damage response factor

Nature Communications, 2019
Oxidative DNA damage is associated with nucleosome respacing and transcriptional changes requiring chromatin remodeling enzymes. Here, the authors reveal that the CHD6 remodeler is a DNA damage response factor that relocates to damaged sites and promotes
Shaun Moore, N. Daniel Berger, Martijn S. Luijsterburg, Cortt G. Piett, Fintan K. T. Stanley, Christoph U. Schräder, Shujuan Fang, Jennifer A. Chan, David C. Schriemer, Zachary D. Nagel, Haico van Attikum, Aaron A. Goodarzi   +11 more
doaj   +1 more source

Effects of anti-lipid peroxidation of Punica granatum fruit extract in endothelial cells induced by plasma of severe pre-eclamptic patients

Journal of Ayurveda and Integrative Medicine, 2017
Preeclampsia is a pregnancy disorder characterized by hypertension and proteinuria. This disorder involves oxidative stress and changes in endothelial homeostasis.
Isri Nasifah, Setyawati Soeharto, Mukhamad Nooryanto   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source