Results 91 to 100 of about 1,121,510 (309)
Direct and Oxidative DNA Damage in a Group of Painters Exposed to VOCs: Dose – Response Relationship
Frontiers in Public Health, 2020 Volatile organic compounds (VOCs) are present in several working activities. This work is aimed at comparing oxidative stress and DNA damage biomarkers to specific VOCs in the occupational exposure of painters.
Renata Sisto +15 more
doaj +1 more source
Micronuclear collapse from oxidative damage [PDF]
ScienceChromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood ...
Melody Di Bona +31 more
openaire +4 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Duality of OGG1: From Genomic Guardian to Redox-Sensitive Modulator in Diseases
AntioxidantsInflammation, malignant tumors, and age-related disorders are all associated with oxidative DNA damage. 8-oxoguanine DNA glycosylase 1 (OGG1), which recognizes and repairs intracellular oxidative damage, was initially thought to play a pivotal role in ...
Ranwei Zhong +4 more
doaj +1 more source
The peroxidation of leukocytes index ratio reveals the prooxidant effect of green tea extract [PDF]
, 2016 Despite tea increased plasma nonenzymatic antioxidant capacity, the European Food Safety Administration (EFSA) denied claims related to tea and its protection from oxidative damage.
Longhitano, Yaroslava +6 more
core +3 more sources
, 2006 3.1. Biomarkers of DNA base oxidation 3.2. Lipid peroxidation induced DNA damage Free radical attack upon DNA generates, among other changes, modified bases. The amount of 8-oxo-7,8-dihydroguanine, one of the most critical lesions in human lymphocytes, was found to be 1.2/106. Gua by a mass spectrometric approach.
Olinski, Ryszard +3 more
openaire
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]
, 2017 Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto +10 more
core +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source