Results 81 to 90 of about 1,121,510 (309)
Potential of cyclodipeptides in combating oxidative stress in chronic diseases
Pharmacological ResearchOxidative stress results from an imbalance between free radicals—such as reactive oxygen species (ROS) and reactive nitrogen species (RNS)—and the body’s antioxidant defenses.
Hamsaletchumi Rajan +4 more
doaj +1 more source
The Nervous System Cytoskeleton under Oxidative Stress
Diseases, 2013 Oxidative stress is a key mechanism causing protein aggregation, cell death and neurodegeneration in the nervous system. The neuronal cytoskeleton, that is, microtubules, actin filaments and neurofilaments, plays a key role in defending the nervous ...
John Gardiner, Robyn Overall, Jan Marc
doaj +1 more source
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils [PDF]
, 2001 The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid arteries occlusion for 5 min.
Al-Dalain, Saied M. +4 more
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Mitochondrial DNA is a sensitive surrogate and oxidative stress target in oral cancer cells.
PLoS ONECellular oxidative stress mediated by intrinsic and/or extrinsic reactive oxygen species (ROS) is associated with disease pathogenesis. Oxidative DNA damage can naturally be substituted by mitochondrial DNA (mtDNA), leading to base lesion/strand break ...
Jingyu Tan, Xinlin Dong, Haiwen Liu
doaj +1 more source
Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]
, 2015 Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core
Separation of oxidatively damaged DNA Nucleobases and Nucleosides on Packed and Monolith C18 Columns by HPLC-UV-EC [PDF]
, 2008 This study involves the incorporation of a commercially available Phenomenex Onyx C18 monolith column into the separation and detection of oxidative DNA damage.
Kelly, Michele C. +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Ecotoxicology and Environmental SafetyFluorosis is a systemic disorder with primary manifestations including skeletal and dental fluorosis, where skeletal fluorosis is associated with cartilage lesions.
Fang-fang Yu +14 more
doaj +1 more source
Redox Biology, 2015 Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to acute kidney injury (AKI ...
Anna J. Dare +5 more
doaj +1 more source