Results 81 to 90 of about 747,150 (312)
Direct and Oxidative DNA Damage in a Group of Painters Exposed to VOCs: Dose – Response Relationship
Frontiers in Public Health, 2020 Volatile organic compounds (VOCs) are present in several working activities. This work is aimed at comparing oxidative stress and DNA damage biomarkers to specific VOCs in the occupational exposure of painters.Renata Sisto, Delia Cavallo, Cinzia Lucia Ursini, Anna Maria Fresegna, Aureliano Ciervo, Raffaele Maiello, Enrico Paci, Daniela Pigini, Monica Gherardi, Andrea Gordiani, Nunziata L'Episcopo, Giovanna Tranfo, Pasquale Capone, Damiano Carbonari, Barbara Balzani, Pieranna Chiarella +15 moredoaj +1 more sourceDifferential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension
, 2023 Patients with arterial hypertension have an increased risk of developing tumors, particularly renal cell carcinoma. Arterial hypertension is linked to DNA damage via the generation of oxidative stress, in which an upregulated renin–angiotensin ...Stefan Störk, Nicole Schupp, Christa, Martin, Martin Christa, Stopper, Helga, Störk, Stefan, Schupp, Nicole, Kraus, Bettina J, Bettina J. Kraus, Eugène H. J. M. Jansen, Helga Stopper, Jansen, Eugène H J M, Moritz Kreutzmann, Kreutzmann, Moritz +13 morecore +1 more sourceNetwork divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers +9 morewiley +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more sourceTetrahydrocurcumin protects against cadmium-induced hypertension, raised arterial stiffness and vascular remodeling in mice [PDF]
, 2012 Copyright: 2014 Sangartit et al. This is an
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permits unrestricted use, distribution, and repro-
duction in any medium, provided the original author and ...Renata Guerra-Sá, Parejo Mora, María Deseada, Ambrosecchia, M, Rodolphe Hamel, Morgado, Mariza Gonçalves, Frédéric Mauny, Poungrat Pakdeechote, Novel N Chegou, Liegeois, Florian, Kim Stanley, Leonardo Fogassi, Plazanet, Marie, Cécile Fournier, Dayse Pereira Campos, Lo Piparo, Franco, Valdilea Gonçalves Veloso, Arnholdt-Schmitt, B., Gallese, V., Jean Chrysostome Gody, Loxton, Andre G., Tiv Michel, Caroline Pereira Bittencourt Passaes (601960), Paulin N Essone, Krustrup, Peter, Ragonezi, Carla, Carl M. Maresh, Paulo Marcos Zech Coelho, Rafaï, Clotaire, Pauline Ferraris (736869), Isabel Velada (673332), Georges Boivin, Catherine Saenz, Muriel Vray, Wu, Siang-Chen, Thierry Frank, Nguyen, Liem Binh Luong, Tamara Giles-Vernick, Kunces, Laura J., Pais, Fabiano Sviatopolk Mirsky, Martínez de Pinillos, Marina ., Weill, Alain, Kraemer, William J., Michèle Bengue (5896889), Pascale Vonaesch, Gallese, V, Andreas Holtermann, Juan C Artistizabal, Guimarães, Monick Lindenmeyer, Adel Rhim, Campos, Dayse Pereira, Dunja Z. Babic (229594), Valentina Cuccio, Daniel J Freidenreich, Anatoly Vasilievich Karalkin, Muscara, Marcelo Nicolas, Daniel J. Freidenreich, Mario Modesto-Mata, Vray, Muriel, Aurélien Gourrier, Sansonetti, Philippe, Laura J. Kunces, Stephen F P Rodrigues, Talignani, L., Sangartit, W, Lemaitre, Estelle, Simone Teixeira, Richard S. Bruno, Peter Krustrup (672720), Modesto-Mata, Mario, Maria Luz Fernandez, Michael Reynolds, Babic, Dunja Z, Alain Weill, Ina Reiche, Cardoso, Cynthia Chester, CUCCIO, Valentina, Loïc Talignani, Praphassorn Surawattanawan, Avilés Regodón, Jesús Miguel, Fagot-Campagna Anne, 吳向宸, Bengue, M., Rodolphe Hamel (233152), Ambrosecchia,M, Jeremias, Wander de Jesus, Ragonezi Carla, Guerra-Sá, Renata, Stevenson, Mario, Tom H Ottenhoff, Marco Carapezza (664878), Essone, Paulin N., Marco Carapezza, Passaes, Caroline Pereira Bittencourt, Céline Chadefaux, Florian Liegeois (5896892), Sylvia Lopes Maia Teixeira, Giles-Vernick, Tamara, Arnholdt-Schmitt, Birgit, Cuccio, V, Valera Hernández, Francisco, Diop, Fode, Philippe Sansonetti, Martinón-Torres, María, Birgit Arnholdt-Schmitt (673334), Marcelo N Muscará, Surawattanawan, P, Milton Ozório Moraes, Laura Tondeur, Ruggirello, Marianna, Mario Stevenson, Paola Dolci, Francesca Ferri, Roney Santos Coimbra, Modesto Mata, Mario, Leonardo Fogassi (664880), Lo Piparo, F, Dayse Pereira Campos (411816), Zajkova, Zuzana, Cocolin, Luca Simone, Monick Lindenmeyer Guimarães (53176), Hans Yssel, Дмитрий Николаевич Греков, Salim, Anna Christina de Matos, Valentina Cuccio (664875), Fogassi, L, Machado, Isabel Daufenback, Galdino, Suely Lins, LO PIPARO, Francesco, Farlay, Delphine, Farra, Alain, Marianna Ambrosecchia, Phinney, Stephen D., Brian R Kupchak, Walzl, Gerhard, GALLESE, Vittorio, Jeff S Volek, Kukongviriyapan, V, Kukongviriyapan, U, Sébastien Breurec, Fodé Diop, Tiv, M., Velada, Isabel, Diogo Gama Caetano, Guillaume Marti, Ionela Gouandjika-Vasilache, Isabel Daufenback Machado, Farsky, Sandra Helena Poliselli, Sa, Renata Guerra, Farlay, Delphine,, Dmitry Nikolaevich Grekov, Missé, Dorothée, Marti, G., Mario Stevenson (45222), Stephen E Greenwald, Burghammer, Manfred,, Barene, Svein, Hamel, Rodolphe, Veloso, Valdiléa G., Franken, Kees L., Gourrier, Aurélien, Gerhard Walzl, José-María Bermúdez de Castro, Valdilea Gonçalves Veloso (5659966), Vittorio Gallese (58439), Mauny, Frédéric, Plazanet, Marie,, Gody, Jean,, Stephen D Phinney, Cynthia Chester Cardoso (601961), Tiv, Michel, Bermúdez De Castro, José-María, Carl M Maresh, Reynolds, Michael,, Cardoso, Hélia, Krustrup, Peter; id_orcid, Pitta, Ivan da Rocha, Sandra H P Farsky, Guillaume Marti (5896895), Carla Ragonezi (673333), Queiroz, Fábio Ribeiro, Fabiano Sviatopolk Mirsky Pais, Stephen D. Phinney, Alfred Penfornis, Mariza Gonçalves Morgado (305691), Velada, I., Babá, Élio Hideo, Michèle Bengue, Bengue, Michèle, Bunk, Oliver, Magdalena Kriel, Sineewanlaya Wichit, Vialet, Amélie ., Gian van der Spuy, Estelle Lemaitre, Alexei Vasilevich Shabunin, Meriem Benabid, Marti, Guillaume, Rania Ben-Romdhane, Birgit Arnholdt-Schmitt, Kriel, Magdalena, Loïc Talignani (834941), Reiche, Ina, Anna Christina de Matos Salim, FOGASSI, Leonardo, Caetano, Diogo Gama, Delphine Farlay, Andreas Holtermann (288296), Francesca Ferri (240583), Petula Bata, Breurec, Sebastien, Crook, Alexander, Fagot-Campagna, Anne, Ivan da Rocha Pitta, Ludovic Bellot-Gurlet, Hélia Cardoso (673335), Milton Ozório Moraes (202227), Carla Ragonezi, Teixeira, Sylvia Lopes Maia, Julien Pompon (798664), Pakdeechote, P, Diogo Gama Caetano (601962), Arnholdt-Schmitt Birgit, Florian Liegeois, Ragonezi, C., Stanley, Kim, Volk, Brittanie M., Isabel Velada, Moraes, Milton Ozório, Fournier Cécile, Sylvia Lopes Maia Teixeira (601963), Vial, Thomas, Eschwège Eveline, Martínez de Pinillos, Marina, Oliveira, Guilherme Correa, Holtermann, Andreas, Marie Plazanet, Fournier, Clarisse, Vittorio Gallese, Wanida Donpunha, Jeff S. Volek, Aïda Bouratbine, Frank, Thierry, Maresh, Carl M., Ferri, F, Penfornis, Alfred, Luca Cocolin, Penfornis Alfred, Sineewanlaya Wichit (110190), Suely Lins Galdino, Oliveira, Guilherme Correa de, Wichit, Sineewanlaya, Richard S Bruno, Tondeur, Laura, María Martinón-Torres, Hans Yssel (233157), Veerapol Kukongviriyapan, Saenz, Catherine, Calero Torralbo, Jesús Miguel, Coelho, Paulo Marcos Zech, Boivin, Georges, Mariza Gonçalves Morgado, Upa Kukongviriyapan, Kees L Franken, FERRI, Francesca, Thomas Vial, Penfornis, A., Cynthia Chester Cardoso, Bruno, Richard S., William J. Kraemer, Svein Barene (5661745), José Roberto Santin, Jamila Ghrab, Oliver Bunk, Reyes González, José Manuel, Brittanie M Volk, Cardoso Hélia, Volek, Jeff S., Anne Fagot-Campagna, Viel Jean-François, Mauny, F., Fagot-Campagna, A., Eveline Eschwège, Weerapon Sangartit, Caroline Pereira Bittencourt Passaes, Santin, José Roberto, Velada Isabel, John Robert Kusel, Yssel, H., Van der Spuy, Gian, Dorothée Missé, Guilherme Correa Oliveira, Hélia Cardoso, Dorothée Missé (233159), Andre G Loxton, Thomas Vial (5896886), Rodríguez Ruiz, Juan, Chadefaux, Céline, Jean-François Viel, Amélie Vialet, Eschwège, E., Gouandjika-Vasilache, Ionela, Julien Pompon, Boivin, Georges,, Liem Binh Luong Nguyen, Анатолий Васильевич Каралкин, Kussel, John Robert, Rodrigues, Stephen Fernandes de Paula, Peter Krustrup, Svein Barene, Алексей Васильевич Шабунин, Teixeira, Simone Aparecida, AMBROSECCHIA, Marianna, Bata, Petula, Burghammer, Manfred, CARAPEZZA, Marco, Élio Hideo Babá, Chegou, Novel N., Weill, Agnès, Vonaesch, Pascale, Павел Алексеевич Дроздов, Talignani, Loïc, Babic, Dunja Z., Karim Aoun, Brian R. Kupchak, Dunja Z Babic, Dolci, Paola, Marianna Ambrosecchia (664872), Mattos, Ana Carolina Alves de, Wichit, S., Fernandez, Maria Luz, Franco Lo Piparo, Reynolds, Michael, Gody, Jean, Chrysostome, Greenwald, SE, Ottenhoff, Tom H., Frieidenreich, Daniel J., Flávio Marcos Gomes Araújo, Artistizabal, Juan C., Ferraris, Pauline, Alain Farra, Martinón Torres, María, William J Kraemer, Marianna Ruggirello, Pauline Ferraris, Michel Tiv, Clotaire Rafaï, Monick Lindenmeyer Guimarães, Carapezza, M, Marina Martínez de Pinillos, Donpunha, W, Pompon, Julien, Brittanie M. Volk, Coimbra, Roney Santos, Fábio Ribeiro Queiroz, Yssel, Hans, Ana Carolina Alves de Mattos, Fodé Diop (797726), Fournier, Cécile, Puente Nilsson, Javier de la, Wander de Jesus Jeremias, Eschwège, Eveline, Cardoso, H., Mauny Frédéric, Araújo, Flávio Marcos Gomes, Manfred Burghammer, Pavel Alexeevich Drozdov, Kusel, John Robert, Bermúdez de Castro, José María, Laura J Kunces, Weill Alain, Vialet, Amélie, Juan C. Artistizabal, Veloso, Valdilea Gonçalves, Kupchak, Brian R., Bellot-Gurlet, Ludovic, Viel, Jean-François, Viel, Jf, Francesco lo Piparo (664879) +377 morecore +1 more sourceHeterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more source
