Results 251 to 260 of about 1,121,510 (309)
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Oxidative damage and fibrogenesis
Free Radical Biology and Medicine, 1997Various chronic disease processes are characterized by progressive accumulation of connective tissue under-going fibrotic degeneration. Evidence of oxidative reactions is often associated with fibrogenesis occurring in liver, lung, arteries, and nervous system.
POLI, Giuseppe, PAROLA, Maurizio
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Perfluorocarbons attenuate oxidative lung damage
Pediatric Pulmonology, 2003AbstractThe aim of this study was to investigate the effect of tidal liquid ventilation (TLV) compared to conventional mechanical ventilation (CMV) on oxidative lung damage in the setting of acute respiratory distress syndrome (ARDS). After repeated lung lavages, 10 minipigs were treated with CMV or TLV for 4 hr before the animals were sacrificed ...
C. DANI +9 more
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1992
Extracellular matrix molecules, such as collagens, are good targets for oxygen free radicals. Collagen is the only protein susceptible to fragmentation by superoxide anion as demonstrated by the liberation of small 4-hydroxyproline-containing-peptides. It seems likely that hydroxyl radicals in the presence of oxygen cleave collagen into small peptides,
J C, Monboisse, J P, Borel
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Extracellular matrix molecules, such as collagens, are good targets for oxygen free radicals. Collagen is the only protein susceptible to fragmentation by superoxide anion as demonstrated by the liberation of small 4-hydroxyproline-containing-peptides. It seems likely that hydroxyl radicals in the presence of oxygen cleave collagen into small peptides,
J C, Monboisse, J P, Borel
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Annual Review of Microbiology, 2003
▪ Abstract  The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms. Redox enzymes are notoriously nonspecific, transferring electrons to any good acceptor with which they make electronic contact.
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▪ Abstract  The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms. Redox enzymes are notoriously nonspecific, transferring electrons to any good acceptor with which they make electronic contact.
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Irradiation damages in lithium oxide
Journal of Nuclear Materials, 1985Abstract Irradiation defects in lithium oxide, irradiated by oxygen ions with energies of 0.5, 0.75, 1.25 and 100 MeV, were studied by an optical absorption technique. In the optical absorption spectra, a dominant absorption band at about 310 nm in wave length and weak bands at about 375 and 570 nm were observed.
K. Noda, Y. Ishh, H. Matsui, H. Watanabe
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Aging and protein oxidative damage
Mechanisms of Ageing and Development, 1994The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidative damage.
S, Agarwal, R S, Sohal
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Endogenous oxidative damage of mtDNA
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999Almost a decade ago, based on analytical measurements of the oxidative DNA adduct 8-oxo-deoxyguanosine (oxo8dG), it was reported that mitochondrial DNA suffers greater endogenous oxidative damage than nuclear DNA. The subsequent discovery that somatic deletions of mitochondrial DNA occur in humans, and that they do so to the greatest extent in ...
K B, Beckman, B N, Ames
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1996
While there is no evidence that nitric oxide (NO) reacts directly with DNA, NO can modify the biopolymer by a variety of indirect pathways. In this review, we describe a selection of the reported mechanisms by which exposure to NO might affect the integrity of DNA, with emphasis on the biological reactive intermediates (BRIs) capable of participating ...
L K, Keefer, D A, Wink
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While there is no evidence that nitric oxide (NO) reacts directly with DNA, NO can modify the biopolymer by a variety of indirect pathways. In this review, we describe a selection of the reported mechanisms by which exposure to NO might affect the integrity of DNA, with emphasis on the biological reactive intermediates (BRIs) capable of participating ...
L K, Keefer, D A, Wink
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Vitamin C Prevents Oxidative Damage
Free Radical Research, 1996Ascorbate-deficiency leads to extensive oxidative damage of proteins and protein loss in the guinea pig tissue microsomes as evidenced by sodium dodecyl sulfate polyacrylamide gel electrophoresis, accumulation of carbonyl, bityrosine as well as by tryptophan loss. Oxidative damage is reversed by ascorbate therapy.
M K, Ghosh +2 more
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