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Oxidative Stress and Organ Damages
Current Hypertension Reports, 2014Oxidative stress plays a pivotal role in various pathological conditions, including hypertension, pulmonary hypertension, diabetes, and chronic kidney disease, with high levels of oxidative stress in target organs such as the heart, pancreas, kidney, and lung.
Sayoko, Ogura, Tatsuo, Shimosawa
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Oxidative damage in chemical teratogenesis
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1997The teratogenicity of many xenobiotics is thought to depend at least in part upon their bioactivation by embryonic cytochromes P450, prostaglandin H synthase (PHS) and lipoxygenases (LPOs) to electrophilic and/or free radical reactive intermediates that covalently bind to or oxidize cellular macromolecules such as DNA, protein and lipid, resulting in ...
P G, Wells +5 more
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Oxidative damage in dengue fever
Free Radical Biology and Medicine, 2009Oxidative stress may be important in the pathogenesis of dengue infection. Using accurate markers of oxidative damage, we assessed the extent of oxidative damage in dengue patients. The levels of hydroxyeicosatetraenoic acid products (HETEs), F(2)-isoprostanes (F(2)-IsoPs), and cholesterol oxidation products (COPs) were measured in 28 adult dengue ...
Seet, R.C.S. +6 more
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Retinal degeneration from oxidative damage
Free Radical Biology and Medicine, 2006Paraquat, a herbicide that generates reactive oxygen species, has been used to probe the oxidative defense systems of lung. In this study, we investigated the effects of paraquat in the retina. There was no significant decline in electroretinogram (ERG) a- or b-wave amplitudes after intravitreous injection of 1 mul of 0.5 mM paraquat in C57BL/6 mice ...
Celia, Cingolani +5 more
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Trash Cache: Secret mitochondrial weapon fights oxidative damage (Oxidative damage)
Science of Aging Knowledge Environment, 2002TAHOE CITY, CALIFORNIA --A good sanitation service keeps trash from swamping the streets. New work presented at the DNA Helicases, Cancer, and Aging Keystone Symposium here identifies the duties of two cellular garbage removers.
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Genetically Encoding Protein Oxidative Damage
Journal of the American Chemical Society, 2008Posttranslational modification of tyrosine residues in proteins, to produce 3-nitrotyrosine (3-NT), is associated with over 50 disease states including transplant rejection, lung infection, central nervous system and ocular inflammation shock, cancer, and neurological disorders (for example, Alzheimer's disease, Parkinson's disease, and stroke).
Heinz, Neumann +4 more
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Oxidative Damage in Huntington's Disease
2004Huntington's disease is a hereditary neurodegenerative disorder, characterized by motor, psychiatric, and cognitive symptoms. The genetic defect responsible for the onset of the disease, expansion of CAG repeats in exon 1 of the gene that codes for huntingtin, has been unambiguously identified.
José, Segovia +1 more
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Iron signaling and oxidant damage
Cardiovascular Toxicology, 2007In this brief essay we discuss the interrelationship between the cellular signaling effects induced by extracellular and intracellular ROS and nitric oxide in the context of doxorubicin (DOX) toxicity.
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Klinische Monatsblatter fur Augenheilkunde, 2010
Oxidative stress is defined as an overflow of oxidative metabolites either in the human body or in a compartment of the body. Today this chemical definition has been slightly modified and encompasses an elevation of oxidative metabolites or a relative deficiency of anti-oxidants.
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Oxidative stress is defined as an overflow of oxidative metabolites either in the human body or in a compartment of the body. Today this chemical definition has been slightly modified and encompasses an elevation of oxidative metabolites or a relative deficiency of anti-oxidants.
openaire +1 more source