Results 261 to 270 of about 747,150 (312)
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1992
Extracellular matrix molecules, such as collagens, are good targets for oxygen free radicals. Collagen is the only protein susceptible to fragmentation by superoxide anion as demonstrated by the liberation of small 4-hydroxyproline-containing-peptides. It seems likely that hydroxyl radicals in the presence of oxygen cleave collagen into small peptides,
J C, Monboisse, J P, Borel
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Extracellular matrix molecules, such as collagens, are good targets for oxygen free radicals. Collagen is the only protein susceptible to fragmentation by superoxide anion as demonstrated by the liberation of small 4-hydroxyproline-containing-peptides. It seems likely that hydroxyl radicals in the presence of oxygen cleave collagen into small peptides,
J C, Monboisse, J P, Borel
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Oxidative and alkylating damage in DNA
Mutation Research/Reviews in Mutation Research, 2003Modification of cellular DNA upon exposure to reactive oxygen and nitrogen species is the likely initial event involved in the induction of the mutagenic and lethal effects of various oxidative stress agents. Evidence has been accumulated for the significant implication of singlet oxygen (1O(2)), generated as the result of UVA activation of endogenous ...
Glaucia R, Martinez +10 more
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Oxidative protein damage and the proteasome
Amino Acids, 2010Protein damage, caused by radicals, is involved in many diseases and in the aging process. Therefore, it is crucial to understand how protein damage can be limited, repaired or removed. To degrade damaged proteins, several intracellular proteolytic systems exist.
S, Grimm, A, Höhn, T, Grune
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Endogenous oxidative damage of mtDNA
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999Almost a decade ago, based on analytical measurements of the oxidative DNA adduct 8-oxo-deoxyguanosine (oxo8dG), it was reported that mitochondrial DNA suffers greater endogenous oxidative damage than nuclear DNA. The subsequent discovery that somatic deletions of mitochondrial DNA occur in humans, and that they do so to the greatest extent in ...
K B, Beckman, B N, Ames
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Aging and protein oxidative damage
Mechanisms of Ageing and Development, 1994The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidative damage.
S, Agarwal, R S, Sohal
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Annual Review of Microbiology, 2003
▪ Abstract The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms. Redox enzymes are notoriously nonspecific, transferring electrons to any good acceptor with which they make electronic contact.
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▪ Abstract The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms. Redox enzymes are notoriously nonspecific, transferring electrons to any good acceptor with which they make electronic contact.
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Depression and oxidative damage to lipids
Psychoneuroendocrinology, 2010Depression is associated with increased morbidity and mortality from cardiovascular and cerebrovascular diseases. Oxidative damage to lipids is one of the key early events in the etiology of atherosclerosis, the pathologic condition that underlies these diseases.
Sarah, Yager +2 more
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Oxidative damage in dengue fever
Free Radical Biology and Medicine, 2009Oxidative stress may be important in the pathogenesis of dengue infection. Using accurate markers of oxidative damage, we assessed the extent of oxidative damage in dengue patients. The levels of hydroxyeicosatetraenoic acid products (HETEs), F(2)-isoprostanes (F(2)-IsoPs), and cholesterol oxidation products (COPs) were measured in 28 adult dengue ...
Seet, R.C.S. +6 more
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Oxidative stress and oxidative damage in chemical carcinogenesis
Toxicology and Applied Pharmacology, 2011Reactive oxygen species (ROS) are induced through a variety of endogenous and exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by ROS may result in oxidative stress and oxidative damage to the cell. This resulting oxidative stress can damage critical cellular macromolecules and/or modulate gene expression pathways ...
James E Klaunig, Zemin Wang, Xinzhu Pu
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1996
While there is no evidence that nitric oxide (NO) reacts directly with DNA, NO can modify the biopolymer by a variety of indirect pathways. In this review, we describe a selection of the reported mechanisms by which exposure to NO might affect the integrity of DNA, with emphasis on the biological reactive intermediates (BRIs) capable of participating ...
L K, Keefer, D A, Wink
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While there is no evidence that nitric oxide (NO) reacts directly with DNA, NO can modify the biopolymer by a variety of indirect pathways. In this review, we describe a selection of the reported mechanisms by which exposure to NO might affect the integrity of DNA, with emphasis on the biological reactive intermediates (BRIs) capable of participating ...
L K, Keefer, D A, Wink
openaire +2 more sources