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Iron signaling and oxidant damage
Cardiovascular Toxicology, 2007In this brief essay we discuss the interrelationship between the cellular signaling effects induced by extracellular and intracellular ROS and nitric oxide in the context of doxorubicin (DOX) toxicity.
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Markers of oxidative damage to DNA: Antioxidants and molecular damage
1999Publisher Summary More than 100 different oxidative modifications have been observed in DNA. However, so far only a few of the base modifications have been used as biomarkers, and of these, the oxidative C-8 adduct of guanine is by far the most studied as either the nucleoside or base.
Loft, Steffen, Poulsen, Henrik E.
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The oxidative environment and protein damage
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005Proteins are a major target for oxidants as a result of their abundance in biological systems, and their high rate constants for reaction. Kinetic data for a number of radicals and non-radical oxidants (e.g. singlet oxygen and hypochlorous acid) are consistent with proteins consuming the majority of these species generated within cells.
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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity
Cell Metabolism, 2020Themis Alissafi +2 more
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Nitric Oxide and Oxidative Damage in the CNS
1997NO is synthesized by a family of enzymes known collectively as NO synthases that catalyze the reaction of L-arginine with molecular oxygen to form NO and L-citrulline. The NO synthases can be divided into 2 main groups: a) constitutive isoforms that are continuously expressed and b) inducible isoforms, the de novo synthesis of which is stimulated by ...
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Oxidative Damage in Parkinson's Disease
Antioxidants & Redox Signaling, 2005Todd B, Sherer, J Timothy, Greenamyre
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Paraquat induced oxidative stress, DNA damage, and cytotoxicity in lymphocytes
Heliyon, 2022Gholamreza Anani Sarab +2 more
exaly