Results 271 to 280 of about 747,150 (312)

Oxidative Stress and Organ Damages

Current Hypertension Reports, 2014
Oxidative stress plays a pivotal role in various pathological conditions, including hypertension, pulmonary hypertension, diabetes, and chronic kidney disease, with high levels of oxidative stress in target organs such as the heart, pancreas, kidney, and lung.
Sayoko, Ogura, Tatsuo, Shimosawa
openaire   +2 more sources

Oxidative Damage to DNA and Aging

Exercise and Sport Sciences Reviews, 2003
Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity
Holly, Van Remmen, Michelle L, Hamilton, A, Richardson   +2 more
openaire   +2 more sources

Oxidative damage and protection of the RPE

Progress in Retinal and Eye Research, 2000
This review provides a model for the role of oxidative stress in the etiology of age-related macular degeneration (AMD). Epidemiological studies of diet, environmental and behavioral risk factors suggest that oxidative stress is a contributing factor of AMD.
J, Cai, K C, Nelson, M, Wu, P, Sternberg, D P, Jones   +4 more
openaire   +2 more sources

Oxidative Damage in Huntington's Disease

2004
Huntington's disease is a hereditary neurodegenerative disorder, characterized by motor, psychiatric, and cognitive symptoms. The genetic defect responsible for the onset of the disease, expansion of CAG repeats in exon 1 of the gene that codes for huntingtin, has been unambiguously identified.
José, Segovia, Francisca, Pérez-Severiano   +1 more
openaire   +2 more sources

Oxidative damage in chemical teratogenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997
The teratogenicity of many xenobiotics is thought to depend at least in part upon their bioactivation by embryonic cytochromes P450, prostaglandin H synthase (PHS) and lipoxygenases (LPOs) to electrophilic and/or free radical reactive intermediates that covalently bind to or oxidize cellular macromolecules such as DNA, protein and lipid, resulting in ...
P G, Wells, P M, Kim, R R, Laposa, C J, Nicol, T, Parman, L M, Winn   +5 more
openaire   +2 more sources

Oxidation of DNA: Damage to Nucleobases

Accounts of Chemical Research, 2009
All organisms store the information necessary to maintain life in their DNA. Any process that damages DNA, causing a loss or corruption of that information, jeopardizes the viability of the organism. One-electron oxidation is such a process. In this Account, we address three of the central features of one-electron oxidation of DNA: (i) the migration of
Sriram, Kanvah, Joshy, Joseph, Gary B, Schuster, Robert N, Barnett, Charles L, Cleveland, Uzi, Landman   +5 more
openaire   +2 more sources

Oxidative Damage to Nucleic Acids

2007
Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects.- Chlorination and Nitration of DNA and Nucleic Acid Components.- Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides.- Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage.- OGG1: From Structural Analysis to the ...
Evans, M. D., Cooke, M. S.
openaire   +2 more sources

Oxidative Damage, Antioxidants and Stroke

Nutritional Neuroscience, 2000
Nutritional factors may have an important role to play in incidence and treatment of stroke. Many epidemiological studies report that people who eat a relatively large quantity of fruits, vegetables and grains have a lower risk of death, particularly from cardiovascular disease.
openaire   +2 more sources

Estrogens receptors and oxidative damage in the liver

Molecular and Cellular Endocrinology, 2002
There is considerable evidence that reactive oxygen species (ROS) have a causative role in chronic hepatic injury and cancer development via direct and indirect mechanisms. Estrogens produce free oxygen radicals through redox cycling and affect cell proliferation, also in the liver.
Farinati F, Cardin R, Bortolami M, GROTTOLA, Antonella, Manno M, Colantoni A, VILLA, Erica   +6 more
openaire   +2 more sources

Perfluorocarbons attenuate oxidative lung damage

Pediatric Pulmonology, 2003
AbstractThe aim of this study was to investigate the effect of tidal liquid ventilation (TLV) compared to conventional mechanical ventilation (CMV) on oxidative lung damage in the setting of acute respiratory distress syndrome (ARDS). After repeated lung lavages, 10 minipigs were treated with CMV or TLV for 4 hr before the animals were sacrificed ...
C. DANI, COSTANTINO, MARIA LAURA, E. MARTELLI, CORNO, CHIARA, FIORE, GIANFRANCO BENIAMINO, G. BUONOCORE, M. LONGINI, A. DI FILIPPO, S. TOZZINI, F. F. RUBALTELLI   +9 more
openaire   +6 more sources