Results 41 to 50 of about 747,150 (312)
Unveiling the crucial role of oxidative stress on steroid hormone receptors
MGM Journal of Medical SciencesOxidative stress is widely recognized as a major contributor to male infertility. Reactive oxygen species (ROS) can interact with various cellular components, causing irreversible damage to the male reproductive system.
Suvendu Ghosh +3 more
doaj +1 more source
Redox Report, 2018 Objective: Glucocorticoids (GCs) can induce oxidative damage in skeletal muscles. The purpose of this study was to demonstrate a high caloric (HC) diet rich in soy oil would change the oxidative stress induced by a GC.
Hongchao Jiao +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2010 PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix.
Kunstmann, Birgit, Osiewacz, Heinz D.
core +1 more source
Oxidative damage and cerebral aging [PDF]
Progress in Neurobiology, 1992 Progress in Neurobiology Vol. 38, pp. 601-609, 1992 Printed in Great Britain. All rights reserved © 1992 Pergamon Press pie OXIDATIVE DAMAGE AND CEREBRAL AGING CARL P. LEBEL* and STEPHEN c. BONDYt • Alkermes, Inc., 26 Landsdowne St, Cambridge, MA 02139, U.S.A. tDepartment of Community and Environmental Medicine, University of California, Irvine, Irvine,
LeBel, Carl P, Bondy, Stephen C
openaire +4 more sources
AntioxidantsReproductive activity is costly in terms of future reproduction and survival. Oxidative stress has been identified as a likely mechanism underlying this cost of reproduction.
Graham Birch +8 more
doaj +1 more source
Redox Biology, 2020 Oxidative damage is one of the major contributors to retinal degenerative diseases such as age-related macular degeneration (AMD), while RPE mediated antioxidant defense plays an important role in preventing retinopathies.
Shuxian Han +12 more
doaj +1 more source
Contribution of environment and genetics to pancreatic cancer susceptibility. [PDF]
PLoS ONE, 2014 Several risk factors have been identified as potential contributors to pancreatic cancer development, including environmental and lifestyle factors, such as smoking, drinking and diet, and medical conditions such as diabetes and pancreatitis, all of ...
Barbara A Hocevar +10 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source