Results 51 to 60 of about 747,150 (312)

Oxidative damage indices for the assessment of subclinical diabetic macrovascular complications

, 2008
Subclinical cardiovascular disease (SCVD), including complications in diabetes, is associated with oxidative damage and precedes future cardiovascular disease (CVD). Hence, assessment and management of oxidative damage is imperative.
Richards, R.S., Jelinek, H., Nwose, E.U., Tinley, P., Kerr, P.G.   +4 more
core   +1 more source

MicroRNA let-7f protects against H2O2-induced oxidative damage in neuroblastoma cells by targeting AKT-2

, 2020
Introduction Alzheimer’s disease (AD) is the leading cause of dementia in late adult life. Emerging evidence shows that microRNAs (miRNAs) play vital roles in the pathogenesis of AD.
Jun-Ling Zhang, Kuo Li, Pei-Yuan Lv, Zhan-Qiang Wang   +3 more
core   +1 more source

Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

Frontiers in Zoology, 2012
Background One central concept in evolutionary ecology is that current and residual reproductive values are negatively linked by the so-called cost of reproduction.
Stier Antoine, Reichert Sophie, Massemin Sylvie, Bize Pierre, Criscuolo François   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation

, 2014
The influence of oxidative stress, diaphragm fatigue and inspiratory muscle training (IMT) on the cytokine response to maximum sustainable voluntary ventilation (MSVV) is unknown.
Gonzalez, JT, Neil C. Williams (16672905), Mills, Dean E., Martin J. McPhilimey (16672902), Gonzalez, Javier T., Gonzalez, J.T., Neil C. Williams, Sharpe, GR, Sharpe, Graham R., McPhilimey, Martin J., Williams, NC, Graham R. Sharpe (16661214), Sharpe, G.R., Mills, Dean, Gonzalez, Javier, McPhilimey, Martin, McPhilimey, MJ, McPhilimey, M.J., Johnson, Michael A., Yvonne A. Barnett, Dean E. Mills (16661205), Yvonne A. Barnett (16661208), Graham R. Sharpe, Barnett, YA, Martin J. McPhilimey, Mills, DE, Javier T. Gonzalez (8473264), Barnett, Yvonne, Javier T. Gonzalez, Johnson, M.A., Sharpe, Graham, Williams, N.C., Williams, Neil C., Dean E. Mills, Johnson, MA, Mills, D.E., Barnett, Yvonne A., Barnett, Y.A., Michael A. Johnson, Michael A. Johnson (1317849), Williams, Neil   +40 more
core   +1 more source

Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage

, 2021
Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and ...
Alejandro Silva-Palacios, Cecilia Zazueta, Cristina Enríquez-Cortina, Mabel Buelna-Chontal, Wylly R. García-Niño   +4 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Exercise-Induced Muscle Damage and Oxidative Stress

Antioxidants, 2018
Exercise-induced muscle damage (EIMD) is associated with muscle soreness or discomfort and amarked decline of muscle strength during the first 12–72 hours post-exercise [1].[...]
Athanasios Z. Jamurtas
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

DNA damage in homocystinuria: 8-oxo‑,8‑dihydro‑2’-deoxyguanosine levels in cystathionine-β-synthase deficient patients and the in vitro protective effect of N-acetyl‑L‑cysteine

Clinical and Biomedical Research, 2018
Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine β-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities.
Camila Simioni Vanzin, Caroline Paula Mescka, Bruna Donida, Desirèe Padilha Marchetti, Carlos Eduardo Jacques, Tatiane Hauschild, Jéssica Lamberty Faverzani, Marion Deon, Dinara Moura, Jenifer Saffi, Daniella de Moura Coelho, Moacir Wajner, Angela T.S. Wyse, Carmen Regla Vargas   +13 more
doaj   +2 more sources