Results 21 to 30 of about 8,623 (211)

Baseline multi-omics signatures could predict therapeutic response to neoadjuvant anti-PD-1 immunochemotherapy in non-small-cell lung cancer. [PDF]

Clin Transl Med
Overview of study design. Metagenomic and plasma/fecal metabolomic studies were performed in 44 NSCLC patients who underwent neoadjuvant tislelizumab therapy plus platinum ‐ based doublet chemotherapy. Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage ...
Cao A, Lin Y, Guan S, Chen Y, Zhai W, Zhou Y, Feng S, Guan Y, Zhang Y, Huang M, Wang X, Long H.   +11 more
europepmc   +2 more sources

Tetrabutylammonium Iodide–Promoted Thiolation of Oxindoles Using Sulfonyl Chlorides as Sulfenylation Reagents

Molecules, 2017
3-Sulfanyloxindoles were synthesised by triphenylphosphine-mediated transition-metal-free thiolation of oxindoles using sulfonyl chlorides as sulfenylation reagents.
Xia Zhao, Aoqi Wei, Xiaoyu Lu, Kui Lu
doaj   +1 more source

GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells

Molecules, 2021
Melanogenesis and melanosome secretion are regulated by several mechanisms. In this study, we found that the oxindole derivative GIF-2209 accelerated melanogenesis associated with the discrimination in the expression and intracellular distributions of ...
Miyu Watanabe, Kyoka Kawaguchi, Yusuke Nakamura, Kyoji Furuta, Hiroshi Takemori   +4 more
doaj   +1 more source

Literature Survey and Further Studies on the 3-Alkylation of N-Unprotected 3-Monosubstituted Oxindoles. Practical Synthesis of N-Unprotected 3,3-Disubstituted Oxindoles and Subsequent Transformations on the Aromatic Ring

Molecules, 2016
The paper provides a comprehensive review of the base-catalysed C3-alkylation of N-unprotected-3-monosubstituted oxindoles. Based on a few, non-systematic studies described in the literature using butyllithium as the deprotonating agent, an optimized ...
Eszter Kókai, Gyula Simig, Balázs Volk
doaj   +1 more source

Photochemical Aryl Radical Cyclizations to Give (E)-3-Ylideneoxindoles

Molecules, 2014
(E)-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilyl)silane and azo ...
Michael Gurry, Ingrid Allart-Simon, Patrick McArdle, Stéphane Gérard, Janos Sapi, Fawaz Aldabbagh   +5 more
doaj   +1 more source

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

Chemistry Proceedings, 2023
Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
doaj   +1 more source

Combination of an Oxindole Derivative with (−)-β-Elemene Alters Cell Death Pathways in FLT3/ITD⁺ Acute Myeloid Leukemia Cells

Molecules, 2023
Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options. Mutations in FLT3 tyrosine kinase receptors make the currently available therapies less responsive.
Jowaher Alanazi, Onur Bender, Rumeysa Dogan, Jonaid Ahmad Malik, Arzu Atalay, Taha F. S. Ali, Eman A. M. Beshr, Ahmed M. Shawky, Omar M. Aly, Yasir Nasser H. Alqahtani, Sirajudheen Anwar   +10 more
doaj   +1 more source

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents [PDF]

Journal of the Brazilian Chemical Society, 2006
Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities.
Cerchiaro, Giselle, Ferreira, Ana Maria da Costa   +1 more
openaire   +3 more sources

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

Viruses, 2023
The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.B79) is essential for viral replication. High throughput in silico/in vitro screening using a focused set of known cysteine protease inhibitors ...
Xin Hu, Elaine Morazzani, Jaimee R. Compton, Moeshia Harmon, Veronica Soloveva, Pamela J. Glass, Andres Dulcey Garcia, Juan J. Marugan, Patricia M. Legler   +8 more
doaj   +1 more source

NaI/PPh3-catalyzed visible-light-mediated decarboxylative radical cascade cyclization of N-arylacrylamides for the efficient synthesis of quaternary oxindoles

Beilstein Journal of Organic Chemistry, 2023
A practical NaI/PPh3-catalyzed decarboxylative radical cascade cyclization of N-arylacrylamides with redox-active esters is described, which is mediated by visible light irradiation.
Dan Liu, Yue Zhao, Frederic W. Patureau
doaj   +1 more source