Results 91 to 100 of about 8,483 (210)

A Facile One-Pot Construction of Succinimide-Fused Spiro[Pyrrolidine-2,3′-Oxindoles] via 1,3-Dipolar Cycloaddition Involving 3-Amino Oxindoles and Maleimides

Molecules, 2018
Increasing interests have been invested in the development of synthetic strategies toward the construction of spiro[pyrrolidine-2,3′-oxindole], which is the core structural skeleton in some compounds with diverse biological activities.
Lunqiang Jin, Feng Liang
doaj   +1 more source

Introduction of Fluorine and Fluorine-Containing Functional Groups [PDF]

, 2013
Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis.
Liang, Theresa, Neumann, Constanze Nicole, Ritter, Tobias   +2 more
core   +1 more source

Exploring Isophorone‐Based Dienones: Comprehensive Insights Into Their Synthesis, Reactivity, and Diverse Applications

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Isophorone is an important motif in synthetic organic chemistry, as it is highly reactive and can get involved in a diverse array of functional group transformations to access various synthetic intermediates and molecular targets. In this context, an important group of compounds is the conjugated or nonconjugated isophorone‐cored dienones, which are ...
M. Saeed Abaee, Mohammad M. Mojtahedi, Sohini Basu Roy   +2 more
wiley   +1 more source

Organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates of isatins

Beilstein Journal of Organic Chemistry, 2012
The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita–Baylis–Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with ...
Hang Zhang, Shan-Jun Zhang, Qing-Qing Zhou, Lin Dong, Ying-Chun Chen   +4 more
doaj   +1 more source

Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles

Molecules, 2018
An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2′-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields.
Yu-Ting Gao, Xiao-Yang Jin, Qi Liu, An-Di Liu, Liang Cheng, Dong Wang, Li Liu   +6 more
doaj   +1 more source

Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols [PDF]

, 2015
The chirality, or ‘handedness’, of a biologically active molecule can alter its physiological properties. Thus it is routine procedure in the drug discovery and development process to prepare and fully characterize all possible stereoisomers of a drug ...
B Simmons, B Wang, BH Lipshutz, C Deutsch, CS Schindler, D Niu, EC Lee, EL McInturff, G Lu, J Hannedouche, J-X Chen, JD Huber, JS Bandar, M Luparia, M Mechler, R Moser, S Krautwald, S Zhu, S Zhu, S-L Shi, Shi-Liang Shi, Stephen L. Buchwald, TJ Barker, X Tian, X-X Yan, Y Huang, Y Miki, Y Yang, Zackary L. Wong   +28 more
core   +1 more source

A palladium-catalysed enolate alkylation cascade for the formation of adjacent quaternary and tertiary stereocentres [PDF]

, 2010
The catalytic enantioselective synthesis of densely functionalized organic molecules that contain all-carbon quaternary stereocentres is a challenge to modern chemical methodology.
A Chieffi, AG Doyle, AG Doyle, Brian M. Stoltz, David E. White, DC Behenna, DE White, F Wu, G Bencivenni, G Helmchen, G Poli, H Li, J Christoffers, J-G Shim, JA Keith, Jan Streuff, JP Das, JT Mohr, JT Mohr, JT Mohr, JT Mohr, LE Overman, MM Abelman, MS Taylor, N Mase, NH Sherden, NT Patil, SC Marinescu, Scott C. Virgil, W Shu, X Liao, Y Hamashima   +31 more
core   +3 more sources

Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds [PDF]

, 2016
Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities.
Aggarwal, Aggarwal, Allgäuer, Barluenga, Bayazit, Brioche, Chen, Choi, Day, Franke, Fulton, Galliford, Gillingham, Guo, Hodgson, Lee, Lemercier, Lerchner, Li, Liu, Maurya, Michael, Nicolle, Ortega, Padwa, Teodoro, Wang, Xu, Zhao, Zhu   +29 more
core   +1 more source

Complete transfer of chirality in an intramolecular, thermal [2 + 2] cycloaddition of allene-ynes to form non-racemic spirooxindoles

Beilstein Journal of Organic Chemistry, 2011
A thermal [2 + 2] cycloaddition reaction of allene-ynes has been used to transform chiral non-racemic allenyl oxindoles into chiral non-racemic spirooxindoles containing an alkylidene cyclobutene moiety.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Crystal structure of methyl 1-methyl-2-oxospiro[indoline-3,2′-oxirane]-3′-carboxylate [PDF]

, 2015
Acknowledgements The authors thank Dr Babu Vargheese, SAIF, IIT, Madras, India, for the data collection.Peer reviewedPublisher ...
Raja, R., Reddy, B. S R, Savithri, M. P., SubbiahPandi, A., Yuvaraj, P. S.   +4 more
core   +2 more sources