Results 51 to 60 of about 8,483 (210)
Molecules, 2018 The use of readily available chiral trans-cyclohexanediamine-benzimidazole derivatives as bifunctional organocatalysts in the asymmetric electrophilic amination of unprotected 3-substituted oxindoles is presented. Different organocatalysts were evaluated;
Llorenç Benavent +2 more
doaj +1 more source
The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis
Angewandte Chemie International Edition, EarlyView.Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio +2 more
wiley +1 more source
Frontiers in Neuroscience, 2018 Gut microbiota produces a wide and diverse array of metabolites that are an integral part of the host metabolome. The emergence of the gut microbiome-brain axis concept has prompted investigations on the role of gut microbiota dysbioses in the ...
Mathilde Jaglin +9 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.A copper‐catalyzed three‐component radical cascade of 1,5‐enynes with toluene and benzoic acids enables regioselective benzyl radical addition to multi‐Π systems, efficiently delivering polysubstituted indenes from an abundant solvent feedstock. ABSTRACT C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an ...
Saideh Rajai‐Daryasarei +7 more
wiley +1 more source
Chemical and Pharmaceutical Bulletin, 1969 The thiation of methyl substituted oxindoles (I) with phosphorous pentasulfide gave the corresponding 2-indolinethiones (II). The 2-indolinethione (II) having more than one hydrogen at 3-position, however, were sensitive towards phosphorous pentasulfide to produce the indolic compounds such as III, IV, V and VI.
TOHRU HINO +3 more
openaire +2 more sources
Asymmetric vinylogous Mukaiyama aldol reaction of isatins under bifunctional organocatalysis: Enantioselective synthesis of substituted 3-hydroxy-2-oxindoles [PDF]
, 2018 A highly enantioselective organocatalytic vinylogous Mukaiyama aldol reaction of silyloxy dienes and isatins under bifunctional organocatalysis is presented. Substituted 3-hydroxy-2-oxindoles are synthesised in good yields and enantioselectivities. These
Alemán, José +3 more
core +2 more sources
ChemistryOpen, EarlyView.In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye +2 more
wiley +1 more source
Chemistry3,3-Dialkoxy-2-oxindoles are prevalent in natural products and exhibit unique biological activities. Among them, acyclic alkoxy analogues show instability in acidic conditions, making access to acyclic isatin ketals highly challenging.
Keisuke Tokushige +2 more
doaj +1 more source
Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update
Beilstein Journal of Organic Chemistry, 2016 Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu +3 more
doaj +1 more source
Asymmetric Pd-NHC*-catalyzed coupling reactions [PDF]
, 2017 Very high asymmetric inductions result in the Pd-catalyzed intramolecular arylation of amides to give 3,3-disubstituted oxindoles when new in situ-generated chiral N-heterocyclic carbene (NHC*) ligands are employed.
Jia, Yixia +3 more
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