Results 81 to 90 of about 2,091,230 (337)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Uniform Oxygen Doping Leads to Superconductivity in FeTe Films [PDF]
arXiv, 2013 FeTe is known to become a superconductor when doped with oxygen. Using layer by layer growth of single crystal films by molecular beam epitaxy (MBE), we have studied how oxygen incorporates. If oxygen is supplied during growth of a layer, it substitutes for tellurium inhomogeneously in oxygen domains that are not associated with superconductivity. When
arxiv
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Magnetic and superconducting properties of RuSr2 Gd1.5Ce0.5Cu2O10-x samples: dependence on the oxygen content and ageing effects [PDF]
, 2005 The magnetic and superconducting properties of RuSr2Gd1.5Ce0.5Cu2O10-x polycrystalline samples with different oxygen doping level are presented. A strong suppression of the superconducting temperature (Tc), as well as a reduction in the superconducting fraction, occurs as the oxygen content is reduced by annealing the samples in oxygen deprived ...
arxiv +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
Advanced Engineering Materials, EarlyView., 2023 The study presents the mechanical and in situ sensing performance of digital light processing‐enabled 2D lattice nanocomposites under monotonic tensile and repeated cyclic loading, and provides guidelines for the design of architectures suitable for strain sensors and smart lightweight structures.
Omar Waqas Saadi +3 more
wiley +1 more source
Issues in Science and Technology Librarianship, 2001 This article reviews the theatre production Oxygen at the San Diego Repertory Theatre in April 2001. It is a collaboration between two well-honored academic research chemists, Carl Djerassi, professor of chemistry at Stanford University and Roald Hoffmann, Frank Rhodes Professor of Humane Letters at Cornell University.
openaire +1 more source