Results 11 to 20 of about 1,643 (175)

Mass Spectrometric Analysis of Purine Intermediary Metabolism Indicates Cyanide Induces Purine Catabolism in Rabbits [PDF]

Metabolites
Purines are the building blocks of DNA/RNA, energy substrates, and cofactors. Purine metabolites, including ATP, GTP, NADH, and coenzyme A, are essential molecules in diverse biological processes such as energy metabolism, signal transduction, and enzyme
Jordan Morningstar, Jangwoen Lee, Sari Mahon, Matthew Brenner, Anjali K. Nath   +4 more
doaj   +2 more sources

Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens [PDF]

Journal of Animal Science and Biotechnology
Background Research on low-protein-level diets has indicated that even though the profiles of essential amino acids (EAAs) follow the recommendation for a normal-protein-level diet, broilers fed low-protein diets failed to achieve productive performance ...
Bin Wang, Xiaodan Zhang, Yongfa Liu, Mingkun Gao, Mi Wang, Yuan Wang, Xinzhi Wang, Yuming Guo   +7 more
doaj   +2 more sources

Simultaneous analysis of allopurinol and oxypurinol using a validated liquid chromatography–tandem mass spectrometry method in human plasma

Journal of Pharmaceutical Analysis, 2017
The present study describes a simple, reliable and reproducible liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for the simultaneous determination of allopurinol and its active metabolite, oxypurinol in human plasma for a pharmacokinetic/
Dhiraj M. Rathod, Keyur R. Patel, Hiren N. Mistri, Arvind G. Jangid, Pranav S. Shrivastav, Mallika Sanyal   +5 more
doaj   +2 more sources

Allopurinol and oxypurinol are hydroxyl radical scavengers [PDF]

FEBS Letters, 1987
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k 2 approx. 109 M−1s−1). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol. Oxypurinol is a better hydroxyl radical scavenger than is allopurinol (k 2 approx.
P.Christopher Moorhouse, Martin Grootveld, Barry Halliwell, John G. Quinlan, John M.C. Gutteridge   +4 more
openalex   +4 more sources

Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis [PDF]

Frontiers in Immunology
ObjectivePrevious research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome–metabolome interface in AS.
Yupeng Lai, Yupeng Lai, Wenli Tang, Xiao Luo, Huihui Zheng, Yanpeng Zhang, Meiying Wang, Guangchuang Yu, Min Yang   +8 more
doaj   +2 more sources

Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture. [PDF]

Nucleic Acids Res
Hedwig V, Spöring M, Ottlinger J, Köse S, Nar H, Schnapp G, Gottschling D, Klein H, Aspnes G, Klugmann M, Hartig JS.   +10 more
europepmc   +3 more sources

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease. [PDF]

Clin Pharmacokinet
Chu WY, Nijman M, Stegeman R, Breur JMPJ, Jansen NJG, Nijman J, van Loon K, Koomen E, Allegaert K, Benders MJNL, Dorlo TPC, Huitema ADR, CRUCIAL trial consortium.   +12 more
europepmc   +3 more sources

Comparison of Aroma and Taste Profiles of Kiwi Wine Fermented with/without Peel by Combining Intelligent Sensory, Gas Chromatography-Mass Spectrometry, and Proton Nuclear Magnetic Resonance [PDF]

Foods
Kiwi wine (KW) is tipically made by fermenting juice from peeled kiwifruit, resulting in the disposal of peel and pomace as by-products. However, the peel contains various beneficial compounds, like phenols and flavonoids.
Bingde Zhou, Xiaochen Liu, Qiuyu Lan, Fang Wan, Zhibo Yang, Xin Nie, Zijian Cai, Bin Hu, Junni Tang, Chenglin Zhu, Luca Laghi   +10 more
doaj   +2 more sources

Population pharmacokinetics, pharmacodynamics and pharmacogenetics modelling of oxypurinol in Hmong adults with gout and/or hyperuricemia. [PDF]

Br J Clin Pharmacol, 2023
Wen YF, Brundage RC, Roman YM, Culhane-Pera KA, Straka RJ.   +4 more
europepmc   +3 more sources

The pharmacokinetics of oxypurinol in people with gout [PDF]

British Journal of Clinical Pharmacology, 2012
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Response to allopurinol in patients with gout is often suboptimal due to large variability in pharmacokinetics.• The sources of the variability in oxypurinol pharmacokinetics have not been systematically identified and quantified.• A therapeutic target 15–23 mg l−1for oxypurinol concentrations has recently been
Sophie L. Stocker, Andrew J. McLachlan, Radojka M. Savić, Carl M. J. Kirkpatrick, Garry G. Graham, Kenneth M. Williams, Richard O. Day   +6 more
openalex   +5 more sources