Results 31 to 40 of about 1,643 (175)
Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation [PDF]
Experimental Cell Research, 2016 Allopurinol and its active metabolite, oxypurinol are widely used in the treatment of gout and hyperuricemia. They inhibit xanthine oxidase (XO) an enzyme in the purine degradation pathway that converts xanthine to uric acid. This investigation examined the effect of allopurinol and oxypurinol on bone formation, cell number and viability, gene ...
Isabel R. Orriss +3 more
openalex +5 more sources
Molecules, 2023 Due to the observed increase in the importance of computational methods in determining selected physicochemical parameters of biologically active compounds that are key to understanding their ADME/T profile, such as lipophilicity, there is a great need ...
Dawid Wardecki +2 more
doaj +1 more source
Effects of allopurinol and of oxypurinol on turkey liver xanthine dehydrogenase [PDF]
FEBS Letters, 1978 Íde Ní Fhaoláin, Michael P. Coughlan
openalex +4 more sources
Frontiers in Neurology, 2019 Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radical (
Jacob B. Ruden +9 more
doaj +1 more source
Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells - Effects on gene expression levels and thiopurine metabolism. [PDF]
PLoS ONE, 2017 Combination treatment with low-dose thiopurine and allopurinol (AP) has successfully been used in patients with inflammatory bowel disease with a so called skewed thiopurine metabolite profile.
Sofie Haglund +3 more
doaj +1 more source
Redox Biology, 2016 Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO ...
Gustavo H. Oliveira-Paula +7 more
doaj +1 more source
BMC Cancer, 2023 Background Pancreatic cancer is a highly lethal disease with no effective treatments. Lactobacillus casei (L. casei) and Lactobacillus reuteri (L. reuteri) exhibited therapeutic effects on several cancers, but their roles in pancreatic cancer are unknown.
Zemin Zhu +7 more
doaj +1 more source
Metabolites, 2023 The mechanisms responsible for the similar muscle growth attained with high- and low-load resistance training (RT) have not yet been fully elucidated. One mechanism is related to the mechanical stimulus and the level of motor unit recruitment; another ...
Denis F. Valério +3 more
doaj +1 more source
HYPERURICEMIA AS A PREDICTOR OF CHRONIC HEART FAILURE
Рациональная фармакотерапия в кардиологии, 2015 Aspects of comorbidity in patients with chronic heart failure are discussed. A focus on hyperuricemia, its effect on the course and prognosis in patients with heart failure, as well as the possibility of its medical correction are maintained.
M. V. Ledyakhova +2 more
doaj +1 more source
Effect of oxidative stress on the activity of human osteoblastic MG63 cells
口腔疾病防治, 2017 Objective To investigate the morphology and proliferation viability in oxidative stress induced damage in human MG63 cells. Methods The MG63 cells were treated with superoxide anion (O2.⁃) produced by different con⁃ centrations of xanthine/xanthine ...
WANG Qiong
doaj +1 more source