Results 41 to 50 of about 1,643 (175)

Depressive Symptoms and the Effectiveness of a Urate‐Lowering Therapy in a Clinical Trial

ACR Open Rheumatology, 2020
Objective This ancillary study examined the impact of depressive symptoms on the effectiveness of a urate‐lowering therapy in the context of a clinical trial.
Sylvie Mrug, Catheryn Orihuela, Elizabeth Rahn, Amy Mudano, Jeffrey Foster, Kenneth Saag, Angelo Gaffo   +6 more
doaj   +1 more source

Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)

Jurnal Biodjati, 2022
Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine.
Dian Fita Lestari, Fatimatuzzahra Fatimatuzzahra, Agnes Petra Sianipar, Shahnaz Shabrina Wulansari   +3 more
doaj   +1 more source

Oxidative stress and heart failure [PDF]

Archives of the Balkan Medical Union, 2019
Oxidative stress is involved in the pathophysiology of many chronic diseases, including heart failure. Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense.
Camelia C. Diaconu
doaj   +2 more sources

Altered Urinary Metabolomics in Hereditary Angioedema

Metabolites, 2022
Hereditary angioedema (HAE) is a rare and potentially life-threatening disease with heterogeneous clinical symptoms. The metabolomic profile of HAE remains unknown.
Xue Wang, Yuxiang Zhi
doaj   +1 more source

Does Allopurinol Prevent Post Endoscopic Retrograde Cholangio- Pancreatography Pancreatitis? A Randomized Double Blind Trial [PDF]

Acta Medica Iranica, 2011
Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a frequent complication either for diagnosis or treatment of pancreatobiliary diseases.
Mohammad Abbasinazari, Amir Houshang Mohammad Alizadeh, Kamyar Moshiri, Mohammad Amin Pourhoseingholi, Mohammad Reza Zali   +4 more
doaj   +1 more source

Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide

Journal of Pharmacological Sciences, 2011
.: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation.
Masashi Tawa, Kohei Yamamizu, Ayman Geddawy, Takashi Shimosato, Takeshi Imamura, Kazuhide Ayajiki, Tomio Okamura   +6 more
doaj   +1 more source

Oxipurinol

Drugs in R & D, 2004
Oxipurinol [alloxanthine, Oxyprim, oxypurinol] is the active metabolite of the only commercially available xanthine oxidase inhibitor, allopurinol. Oxipurinol is also a xanthine oxidase inhibitor. Oxipurinol is currently being developed by Cardiome Pharma.
openaire   +2 more sources

Comparative Study of the Lipophilicity of Selected Anti-Androgenic and Blood Uric Acid Lowering Compounds

Molecules, 2022
This study aimed to evaluate the lipophilicity of a series substances lowering the concentration of uric acid in blood and anti-androgen drugs by thin-layer chromatography in reversed-phase systems (RP-TLC, RP-HPTLC) and computational methods.
Dawid Wardecki, Małgorzata Dołowy, Katarzyna Bober-Majnusz, Josef Jampilek   +3 more
doaj   +1 more source

Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4‐Linked Hereditary Spastic Paraplegia—A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Graphical representation of spasticity and medication changes. (A) Temporal course of lower limb spasticity measured by MAS scores. Following initiation of allopurinol 300 mg daily at baseline (red dashed line), there was a rapid and sustained improvement in spasticity from severe (MAS = 4) to mild (MAS = 1.8) over 12 months of follow‐up, represented ...
Ziad W. Elmezayen, Hossam Salameh, Asem Afana, Anwar Zahran   +3 more
wiley   +1 more source

Allopurinol Treatment Improves Cognitive Skills, Adaptive Behavior, and Biochemical Markers in Young Patients With Adenylosuccinate Lyase Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Adenylosuccinate lyase deficiency (ADSLD) is a rare neurological disorder characterized by psychomotor retardation, autistic behaviors, and seizures, with no specific treatment available. ADSL catalyzes the transformation of succinylaminoimidazole carboxamide ribotide (SAICAr) to AICAR, and succinyl‐AMP (S‐AMP) to AMP.
Bérangère Rousselot‐Pailley, Michaela Semeraro, Fabienne Marquant, Laurence Robel, Cyril Gitiaux, Anna Kaminska, Fanny Mochel, Prissile Bakouboula, Caroline Elie, Carole Hennequin, Irène Ceballos‐Picot, Sylvia Sanquer, Pascale de Lonlay   +12 more
wiley   +1 more source