Results 51 to 60 of about 1,643 (175)
Prediction of ADMET, molecular docking, DFT, and QSPR of potential phytoconstituents from Ambrosia maritima L. targeting xanthine oxidase [PDF]
PharmaciaThis study aimed to evaluate the xanthine oxidase (XO) inhibitory activities of seven compounds identified in the potent antioxidant ethyl acetate fraction of Ambrosia maritima L. using various computational tools.
Wadah Osman +8 more
doaj +3 more sources
Ecotoxicology and Environmental Safety, 2021 Municipal wastewater treatment plant (WWTP) effluents are significant sources of organic and inorganic pollutants to aquatic ecosystems. Several studies have shown that the health of aquatic organisms can be adversely impacted following exposure to these
Michel A. Defo +8 more
doaj +1 more source
Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 425-441, October 2025.ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval +2 more
wiley +1 more source
Phloroglucinol Derivatives from Dryopteris crassirhizoma as Potent Xanthine Oxidase Inhibitors
Molecules, 2020 Dryopteris crassirhizoma rhizomes are used as a traditional medicine in Asia. The EtOAc extract of these roots has shown potent xanthine oxidase (XO) inhibitory activity. However, the main phloroglucinols in D.
Heung Joo Yuk +3 more
doaj +1 more source
Effect of Oxypurinol on Renal Reperfusion Injury in the Rat
Renal Failure, 1993 Oxygen-based free radicals produced by the enzyme xanthine oxidase may be involved in postischemic reperfusion injury. To determine whether oxypurinol, a xanthine oxidase inhibitor and the major metabolite of allopurinol, attenuates renal ischemic reperfusion injury, and, if so, to determine its most effective dose, oxypurinol 2.5, 5, 10 or 20 mg/kg BW
J J, Dillon, S H, Grossman, W F, Finn
openaire +2 more sources
Mechanism for the Increased Permeability in Endothelial Monolayers Induced by Elastase
Mediators of Inflammation, 1994 The aim of this study was to investigate the mechanism for the increase in endothelial permeability induced by human neutrophil elastase (HNE). Pretreatment of bovine pulmonary artery endothelial cells (BPAEC) with HNE(0-30 μg/ml) for 1 h produced a ...
N. Suzuki, Y. Ishii, S. Kitamura
doaj +1 more source
International Journal of Rheumatic Diseases, Volume 28, Issue 7, July 2025.ABSTRACT Background In 2018, the Chinese Society of Endocrinology developed the “Chinese guideline for diagnosis and treatment of hyperuricemia and gout (2019)”. Over the past 5 years, clinical and experimental research has expanded our knowledge of gout, resulting in novel diagnostic and therapeutic approaches.
Mingshu Sun +30 more
wiley +1 more source
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Its progressively expanding, fluid‐filled renal cysts eventually lead to end‐stage renal disease. Despite the relatively high prevalence, treatment options are currently limited to a single drug approved by the FDA and EMA.
Alina Meyer +9 more
wiley +1 more source
Metabolic factors determining the effectiveness of hypouricemic treatment of gouty arthritis
Bolʹ, Sustavy, Pozvonočnik, 2018 Background. The treatment of some forms of articular pathology with gout remains insufficiently effective, and often it’s impossible to achieve normal indicators of uricemia on the background of uric acid-normalizing medicines.
O.V. Syniachenko +3 more
doaj +1 more source
Population Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics Modeling of Oxypurinol in Hmong Adults with Gout and/or Hyperuricemia [PDF]
, 2022 Ya‐Feng Wen +4 more
openalex +1 more source