Results 71 to 80 of about 1,643 (175)

Serum metabonomic study to explore the amelioration mechanisms of co‐fermented collagen peptide‐jackfruit juice on the immunosuppressed mice

eFood, Volume 5, Issue 1, February 2024.
Metabolomics approach developed herein provides novel insight onto the metabolic disturbances associated with immunosuppression, and helped to further understand the mechanism of FPJ and provide a basis for further research. Abstract The main purpose of this study was to investigate the improvement effect and serum metabolomic analysis of co‐fermented ...
Tingting Ma, Ming Cheng, Xin Wen, Kexue Zhu, Xin Zhang, Chao Zhao, Hesham R. El‐Seedi, Xiangdong Lin, Yongcheng Li, Lulu Zhu, Jun Cao, Chuan Li   +11 more
wiley   +1 more source

How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

Arthritis Research & Therapy, 2018
Objective Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU).
Lisa K. Stamp, Peter T. Chapman, Murray L. Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth   +7 more
doaj   +1 more source

Patients with naproxen‐induced liver injury display T‐cell memory responses toward an oxidative (S)‐O‐desmethyl naproxen metabolite but not the acyl glucuronide

Allergy, Volume 79, Issue 1, Page 200-214, January 2024.
CD4+ and CD8+ T‐cell hepatic infiltration is detected in a biopsy from a patient with NSAID (nonsteroidal anti‐inflammatory drug)‐induced liver injury. The naproxen metabolite, desmethyl naproxen, activates T‐cells from patients with naproxen‐induced liver injury. Whilst bioactivation at the carboxylate group is widely hypothesized to be pathogenic for
Paul Thomson, Nik Fragkas, Laila M. Kafu, Guruprasad P. Aithal, M. Isabel Lucena, Luigi Terracciano, Xiaoli Meng, Munir Pirmohamed, Dominique Brees, Gerd A. Kullak‐Ublick, Alex Odermatt, Thomas Hammond, Michael Kammüller, Dean J. Naisbitt   +13 more
wiley   +1 more source

Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials

BMC Cardiovascular Disorders, 2018
Background Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from ...
Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d’Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein, Guilherme Gomes Dias Campos   +8 more
doaj   +1 more source

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Journal of Translational Medicine
Background Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, and coxsackievirus B3.
JinFang Hao, Xiaoyan Zhang, Ruixian Hu, Xiufeng Lu, Hui Wang, Yuanhong Li, Kai Cheng, Qingshan Li   +7 more
doaj   +1 more source

Clinical and pathogenetic importance of hormonal natriuretic peptides in gout

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. In addition to purine metabolism disorders, systems of pro-inflammatory cytokines, matrix metalloproteinases and eicosanoids, various medium molecular weight compounds can participate in the pathogenesis of gout, including natriuretic ...
O.V. Syniachenko, D.M. Fedorov, M.V. Yermolaieva, V.V. Pylypenko   +3 more
doaj   +1 more source

Oxypurinol, allopurinol and allopurinol‐1‐riboside in plasma following an acute overdose of allopurinol in a patient with advanced chronic kidney disease [PDF]

, 2011
Diluk R. W. Kannangara, Darren M. Roberts, Timothy J. Furlong, Garry G. Graham, Kenneth M. Williams, Richard O. Day   +5 more
openalex   +1 more source

Comparative assessment of primary and paraneoplastic gout in lung cancer

Zaporožskij Medicinskij Žurnal, 2018
Introduction. Lung cancer (LС) is the most common cause of the so-called paraneoplastic syndrome (PNPS) development, caused by the complex immunoinflammatory, degenerative and vascular distant changes.
O. V. Syniachenko, Yu. V. Dumanskyi, Ye. D. Yehudina, O. Ye. Chernyshova, P. A. Stepko, D. M. Fedorov   +5 more
doaj   +1 more source

Direct injection analysis of oxypurinol and metformin in wastewater by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry

, 2022
Qiuda Zheng, Pradeep Dewapriya, Geoff Eaglesham, Tim Reeks, Jack Thompson, Fahad Ahmed, Pritesh Prasad, Kevin V. Thomas, Jochen F. Mueller, Phong K. Thai   +9 more
openalex   +1 more source