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The Discovery and Analysis of P Bodies
2012The last decade has seen the discovery of a conserved class of cytoplasmic mRNP (messenger Ribonucleic Acid—Protein complexes) aggregates called Processing Bodies or P Bodies (Sheth and Parker 2003). They belong to a growing list of cytoplasmic mRNP aggregates, many of which are compositionally similar to P Bodies and consist of a host of translational
Saumya, Jain, Roy, Parker
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Processing body (P-body) and its mediators in cancer
Molecular and Cellular Biochemistry, 2022In recent years, processing bodies (P-bodies) formed by liquid-liquid phase separation, have attracted growing scientific attention due to their involvement in numerous cellular activities, including the regulation of mRNAs decay or storage. These cytoplasmic dynamic membraneless granules contain mRNA storage and decay components such as deadenylase ...
Bernard Nsengimana +7 more
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GW/P-Bodies and Autoimmune Disease
2012Human autoantibodies have performed admirably in the service of characterizing GW/P-bodies. These antibodies have provided a critical point of reference by which other proteins have been shown to be components of GW/P-bodies. In addition,autoantibodies have been used to identify new GW/P-body components, including Ge-l, GW182, RAP55, and YB-1.
Donald B, Bloch +2 more
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RNAi and the P-body connection
Nature Cell Biology, 2005Cytoplasmic processing bodies, also known as P-bodies, concentrate enzymes that are involved in mRNA turnover and sequester mRNAs away from the translational machinery. Strong evidence now connects the RNA interference machinery with P-body formation.
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Intracellular trafficking of RNASET2, a novel component of P‐bodies
Biology of the Cell, 2011AbstractBackground informationThe ribonucleases (RNases) constitute a heterogeneous group of enzymes, which exert diverse and specific biological functions. Several RNases have been shown to control gene expression and cell differentiation. RNASET2, a novel member of the Rh/T2/S family of RNases, exerts micro‐environmental control of malignancy in ...
Vidalino L. +6 more
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Science Signaling, 2011
Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation.
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Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation.
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P-bodies and mitochondria: Which place in RNA interference?
Biochimie, 2012Micro-RNAs (miRNAs) are major actors of RNA interference (RNAi), a regulation pathway which leads to translational repression and/or degradation of specific mRNAs. They provide target specificity by incorporating into the RISC complex and guiding its binding to mRNA. Since the discovery of RNAi, many progresses have been made on the mechanism of action
Ernoult-Lange, Michèle +3 more
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Hsp90 is involved in the formation of P-bodies and stress granules
Biochemical and Biophysical Research Communications, 2011Previously, we found that treatment of cells with the Hsp90 inhibitor geldanamycin (GA) leads to a substantial reduction in the number of processing bodies (P-bodies), and also alters the size and subcellular localization of stress granules. These findings imply that the chaperone activity of Hsp90 is involved in the formation of P-bodies and stress ...
Ken, Matsumoto +7 more
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RNA
Processing bodies (P-bodies) are membraneless organelles in eukaryotic cells that play a central role in mRNA metabolism, including mRNA decay, storage, and translational repression. However, the molecular mechanisms governing their assembly remain incompletely understood.
Yu-Hsuan Cheng +6 more
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Processing bodies (P-bodies) are membraneless organelles in eukaryotic cells that play a central role in mRNA metabolism, including mRNA decay, storage, and translational repression. However, the molecular mechanisms governing their assembly remain incompletely understood.
Yu-Hsuan Cheng +6 more
openaire +3 more sources