Results 91 to 100 of about 9,946 (182)

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin [PDF]

Nephrology Dialysis Transplantation, 2009
Protein-bound uraemic retention solutes, including p-cresyl sulfate and indoxyl sulfate, contribute substantially to the uraemic syndrome. These and several other uraemic retention solutes originate from intestinal bacterial protein fermentation. We investigated whether the prebiotic oligofructose-enriched inulin reduced serum concentration of p-cresyl
Björn K I, Meijers, Vicky, De Preter, Kristin, Verbeke, Yves, Vanrenterghem, Pieter, Evenepoel   +4 more
openaire   +2 more sources

Use of a recombinant pseudorabies virus to analyze motor cortical reorganization after unilateral facial denervation [PDF]

, 2005
A unilateral facial nerve injury (n7x) was found to influence the transcallosal spread of the attenuated strain of pseudorabies virus (PRV Bartha) from the affected (left) primary motor cortex (MI) to the contralateral MI of rats.
Boda, Krisztina, Boldogkői, Zsolt, Farkas, Tamás, Horváth, Szatmár, Janka, Zoltán, Kis, Zsolt, Pankotai, Eszter, Prandovszky, Emese, Toldi, József   +8 more
core   +1 more source

Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

Toxins, 2017
Elevated circulating uremic toxins are associated with a variety of symptoms and organ dysfunction observed in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are representative uremic toxins that exert various
Emiko Sato, Daisuke Saigusa, Eikan Mishima, Taeko Uchida, Daisuke Miura, Tomomi Morikawa-Ichinose, Kiyomi Kisu, Akiyo Sekimoto, Ritsumi Saito, Yuji Oe, Yotaro Matsumoto, Yoshihisa Tomioka, Takefumi Mori, Nobuyuki Takahashi, Hiroshi Sato, Takaaki Abe, Toshimitsu Niwa, Sadayoshi Ito   +17 more
doaj   +1 more source

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang, Xin Hua, Ziwei Fan, Jiaxin Zhao, Yuan Zhang, Qiaoyi Zhang, Xi Qu, Shengli Pan, Bingbing Wan, Shiyin Yang, Jia Li, Xu Zhang   +11 more
wiley   +1 more source

The effect of isohydric hemodialysis on the binding and removal of uremic retention solutes. [PDF]

PLoS ONE, 2018
BACKGROUND:There is growing evidence that the accumulation of protein- bound uremic retention solutes, such as indoxyl sulfate, p-cresyl sulfate and kynurenic acid, play a role in the accelerated cardiovascular disease seen in patients undergoing chronic
Aleksey Etinger, Sumit R Kumar, William Ackley, Leland Soiefer, Jonathan Chun, Prabjhot Singh, Eric Grossman, Albert Matalon, Robert S Holzman, Bjorn Meijers, Jerome Lowenstein   +10 more
doaj   +1 more source

A versatile standard for bathochromic fluorescence based on intramolecular FRET. [PDF]

, 2011
A perylene and a terrylene tetracarboxylic bisimide dyad was prepared in which an efficient energy transfer from the former to the latter is observed. The absorption spectrum of this compound covers a broad range.
Adachi, Andreas Walter, Dawson, Demas, Desilets, Erik Rosenbaum, Feiler, Heinz Langhals, Holtrup, Kaiser, Kalinin, Langhals, Langhals, Langhals, Langhals, Langhals, Langhals, Langhals, Langhals, Lennart B.-Å. Johansson, Levenberg, Melhuish, Nolde, Sakamoto, Weber, Wehmeier   +25 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Differences in gut microbiota composition are an important reason for lower serum p-cresol sulfate levels in anuric peritoneal dialysis patients compared to hemodialysis patients

Current Research in Microbial Sciences
Background: Patients with end-stage kidney disease (ESKD) accumulate toxic metabolites that contribute to severe clinical complications. Peritoneal dialysis (PD) and hemodialysis (HD) exhibit distinct capacites for toxin clearance.
Min Lu, Shulan Guo, Zhaoying Nie, Ji Ji, Yimei Wang, Xiaotian Jiang, Lin Zhang, Bo Xiang, Weiwei Wu, Jun Ji, Jianzhou Zou, Xiaoqiang Ding, Xiaofang Yu   +12 more
doaj   +1 more source

Jingxin Zhidong Formula Alleviates Tic Disorder via Modulation of Microglial IKK/NF‐κB Signaling and Striatal Neurotransmitter Homeostasis

Brain and Behavior, Volume 16, Issue 4, April 2026.
Jingxin Zhidong Formula (JXZDF) alleviates tic‐like behaviors in a rat model of tic disorder (TD) by restoring the excitatoryinhibitory neurotransmitter balance in the striatum—reducing glutamate and increasing GABA levels—and by suppressing microglial IKK/NF‐κBmediated neuroinflammation. These effects are dose‐dependent and involve inhibition of NF‐κB
Fei Fan, Jing Yang, Zenghui Niu, Chengkui Xiu, Fei Han   +4 more
wiley   +1 more source