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P-glycoprotein and chronic rhinosinusitis
World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018 Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses.
Marcel M. Miyake +2 more
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Computationally accelerated identification of P-glycoprotein inhibitors [PDF]
PLoS ONEOverexpression of the polyspecific efflux transporter, P-glycoprotein (P-gp, MDR1, ABCB1), is a major mechanism by which cancer cells acquire multidrug resistance (MDR), the resistance to diverse chemotherapeutic drugs.
Lauren A. McCormick +5 more
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Regulation of P-Glycoprotein during Oxidative Stress [PDF]
AntioxidantsP-glycoprotein (Pgp, ABCB1, MDR1) is an efflux transporter protein that removes molecules from the cells (outflow) into the extracellular space. Pgp plays an important role in pharmacokinetics, ensuring the absorption, distribution, and excretion of ...
Aleksey V. Shchulkin +4 more
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Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption [PDF]
Nature CommunicationsP-glycoprotein (P-gp) is a crucial drug efflux transporter in the gastrointestinal tract, reducing drug uptake and expelling harmful xenobiotics to prevent pathological changes.
Qinghua Wu +10 more
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Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis [PDF]
Journal of the Serbian Chemical Society, 2021 In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR).
Krstić Gordana B. +6 more
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First report of nt230(del4) mutation in the MDR1 gene in German Shepherds in Southern Brazil
Ciência Rural, 2021 : The P-glycoprotein (P-gp) is a transmembrane protein encoded by the MDR1 gene that functions as a biological barrier by extruding toxins and xenobiotics out of cells.
Ananda da Rocha Pires +4 more
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Molecular Oncology, 2023 Chemotherapy resistance is a persistent clinical problem in relapsed high‐risk neuroblastomas. We tested a panel of 15 drugs for sensitization of neuroblastoma cells to the conventional chemotherapeutic vincristine, identifying tariquidar, an inhibitor ...
Lisa Rösch +9 more
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The Effect of Rifampicin on the Induction of MDR1/P-gp Activity in Proinflammatory Human Macrophages
Антибиотики и Химиотерапия, 2022 Background. The effect on the activity of the multidrug resistance protein P-glycoprotein (P-gp, MDR1 gene) in pro-inflammatory (M1) human macrophages is considered one of the promising strategies for increasing the effectiveness of the treatment in ...
E. N. Pavlova +6 more
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P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers
Frontiers in Oncology, 2020 P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP) binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to successful pharmacotherapy of cancers.
Anna Seelig
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