Results 11 to 20 of about 507,211 (287)

Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs

Pharmaceutics, 2021
For developing oral drugs, it is necessary to predict the oral absorption of new chemical entities accurately. However, it is difficult because of the involvement of efflux transporters, including P-glycoprotein (P-gp), in their absorption process.
Yusuke Kono, Iichiro Kawahara, Kohei Shinozaki, Ikuo Nomura, Honoka Marutani, Akira Yamamoto, Takuya Fujita   +6 more
doaj   +1 more source

Pharmacokinetic interactions: The effects of selected herbal extracts on permeation of P-glycoprotein substrate drugs across excised pig intestinal tissue [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: There is growing concern that co-administered herbal medicines may alter the pharmacokinetics and, therefore, the efficacy and toxicity of Western drugs.
Bianca Peterson, Corneli Jacobsz, Josias Hamman, Alvaro Viljoen, Dewald Steyn   +4 more
doaj   +1 more source

P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain

Journal of Pharmacological Sciences, 2016
Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced ...
Takehiro Mukae, Wakako Fujita, Hiroshi Ueda   +2 more
doaj   +1 more source

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway

Pharmaceutical Biology, 2020
Context Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.
Lin Yang, Chengda Zhang, Jiaoting Chen, Sheng Zhang, Guixuan Pan, Yanfei Xin, Lin Lin, Zhenqiang You   +7 more
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The Effect of the Canine ABCB1‐1Δ Mutation on Sedation after Intravenous Administration of Acepromazine

Journal of Veterinary Internal Medicine, 2016
Background Dog breeds with the ABCB1‐1Δ mutation have substantially truncated nonfunctional P‐glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine.
D. Deshpande, K.E. Hill, K.L. Mealey, J.P. Chambers, M.A. Gieseg   +4 more
doaj   +1 more source

Effect of ethylmethylhydroxypyridine succinate on the functional activity of the transporter P-glycoprotein in the blood-brain barrier of rats under normal conditions and under hypoxic hypoxia

Фармакокинетика и Фармакодинамика, 2022
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells and ...
P. Yu. Mylnikov, A. V. Shchulkin, I. V. Chernykh, E. N. Yakusheva   +3 more
doaj   +1 more source

Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition

Frontiers in Medicine, 2023
Inflammatory Bowel Disease (IBD) affects approximately 0.3% of the global population, with incidence rates rising dramatically worldwide. Emerging evidence points to an interplay between exposome factors such as diet and gut microbiota, host genetics ...
Allan Stensballe, Allan Stensballe, Tue Bjerg Bennike, Gitte Ravn-Haren, Alicja Mortensen, Christopher Aboo, Christopher Aboo, Lina Almind Knudsen, Malte C. Rühlemann, Svend Birkelund, Corinne Bang, Andre Franke, Ulla Vogel, Ulla Vogel, Axel Kornerup Hansen, Vibeke Andersen, Vibeke Andersen, Vibeke Andersen   +17 more
doaj   +1 more source

Effects of P-Glycoprotein and Its Inhibitors on Apoptosis in K562 Cells

Molecules, 2014
P-glycoprotein (P-gp) is a major factor in multidrug resistance (MDR) which is a serious obstacle in chemotherapy. P-gp has also been implicated in causing apoptosis of tumor cells, which was shown to be another important mechanism of MDR recently.
Yaqiong Zu, Zhiyong Yang, Songshan Tang, Ying Han, Jun Ma   +4 more
doaj   +1 more source

Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein. [PDF]

PLoS ONE, 2011
Human P-glycoprotein (P-gp) is an ATP-binding cassette multidrug transporter that confers resistance to a wide range of chemotherapeutic agents in cancer cells by active efflux of the drugs from cells.
Zsolt Bikadi, Istvan Hazai, David Malik, Katalin Jemnitz, Zsuzsa Veres, Peter Hari, Zhanglin Ni, Tip W Loo, David M Clarke, Eszter Hazai, Qingcheng Mao   +10 more
doaj   +1 more source

Multidrug resistance factor - glycoprotein P in rheumatoid arthritis

Научно-практическая ревматология, 2003
Objective. To assess expression of P-glycoprotein (Pgp) on peripheral blood (PB) lymphocytes and its changes during therapy in pts with rheumatoid arthritis (RA). Methods. 51 RA pts and 11 healthy donors (control group) were examined.
I P Kolosova
doaj   +1 more source