CAB39 Promotes the Proliferation of Nasopharyngeal Carcinoma CNE-1 Cells via Up-Regulating p-JNK [PDF]
Cancer Management and Research, 2020 Lifen Peng,1 Hailan Yan,2 Shuyi Qi,3 Lifei Deng4 1Department of Otolaryngology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, People’s Republic of China; 2Department of Clinical Medicine, Xi’an ...
Peng L, Yan H, Qi S, Deng L
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The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time [PDF]
Frontiers in Cell and Developmental Biology, 2021 This study aims to investigate the prognostic significance of p-JNK in breast cancer patients receiving neoadjuvant chemotherapy (NACT) and analyze the relationship between anisomycin, p-JNK.
Li Chen +9 more
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Inhibition of p-mTOR represses PS1 transcription by reducing p-JNK [PDF]
Frontiers in Bioscience-Landmark, 2020 Presenilin-1 (PS1) is the catalytic subunit of gamma-secretase. PS1 cleaves beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the cytoplasm.
Hriday K. Das, Silahis S. Hontiveros
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REDD1 Affects Proliferation, Apoptosis, Migration, and Colony Formation via p-ERK and p-JNK Signaling in Lung Adenocarcinoma Cells Under Hypoxia [PDF]
BiomedicinesBackground: Regulated in development and DNA damage response 1 (REDD1) is a stress-related protein that is found to be involved in tumor progression. The role and internal regulatory mechanism of REDD1 in lung adenocarcinoma (LUAD) remain unidentified as
Xiaoyu Fang +3 more
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Di-san junyi daxue xuebao, 2021 Objective To investigate the role and mechanism of Toll-like receptor 9 (TLR9) in hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells (RPASMCs).
WU Qijian +5 more
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Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]
, 2015 c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan +8 more
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Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29 [PDF]
, 2020 Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the side effects and the emergence of
Calderón-Montaño, Jose M. +4 more
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Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells [PDF]
, 2016 Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete CML LSC are needed to enhance the ...
Agarwal, Puneet +9 more
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KLF14 activates the JNK-signaling pathway to induce S-phase arrest in cervical cancer cells
Frontiers in Immunology, 2023 ObjectiveTo explore the role of Krüppel-like factor 14 (KLF14) and its underlying mechanism(s) of action in cell-cycle regulation in cervical cancer.MethodsLentiviral infection was used to construct KLF14, KLF14 zinc-finger structural mutations, and ...
Ying Du +4 more
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Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]
, 2012 Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
A Barbarulo +63 more
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