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The Replication Function of Rabies Virus P Protein Is Regulated by a Novel Phosphorylation Site in the N-Terminal N Protein-Binding Region [PDF]

Viruses
The rabies virus (RABV) phosphoprotein (P protein) has multiple functions, including acting as the essential non-catalytic cofactor of the viral polymerase (L protein) for genome replication and transcription; the principal viral antagonist of the ...
Ericka Tudhope, Camilla M. Donnelly, Ashish Sethi, Cassandra David, Nicholas Williamson, Murray Stewart, Jade K. Forwood, Paul R. Gooley, Gregory W. Moseley   +8 more
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A Potent Micron Neoantigen Tumor Vaccine GP‐Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models

Advanced Science, 2022
Therapeutic tumor neoantigen vaccines have been widely studied given their good safety profile and ability to avoid central thymic tolerance. However, targeting antigen‐presenting cells (APCs) and inducing robust neoantigen‐specific cellular immunity ...
Zhe Jing, Shuqing Wang, Keyuan Xu, Qian Tang, Wenjing Li, Wei Zheng, Haobo Shi, Kailing Su, Yanting Liu, Zhangyong Hong   +9 more
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Multifunctional properties of the transmembrane LPxTG-motif protein derived from Limosilactobacillus reuteri SH-23

Journal of Dairy Science, 2023
: The LPxTG-motif protein is an important transmembrane protein with high hydrophilicity and stability, as evidenced by its stress tolerance and adhesion ability.
Qianwen Ye, Lifeng Lao, Ao Zhang, Yiman Qin, Manli Zong, Daodong Pan, Hua Yang, Zhen Wu   +7 more
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Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I [PDF]

PeerJ, 2017
Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions.
Tianyao Guo, Zhigui Duan, Jia Chen, Chunliang Xie, Ying Wang, Ping Chen, Xianchun Wang   +6 more
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Mild‐Photothermal Effect Induced High Efficiency Ferroptosis‐Boosted‐Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme

Advanced Science, 2023
A core‐shell‐structured Cu2O@Mn3Cu3O8 (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)‐activated copper ionophore to achieve safe and efficient cuproptosis.
Wei Chen, Wenyu Xie, Zhimin Gao, Chen Lin, Meiling Tan, Yaru Zhang, Zhiyao Hou   +6 more
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Nanozyme for tumor therapy: Surface modification matters

Exploration, 2021
As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease of production and modification, paving the way for its biomedical ...
Guoheng Tang, Jiuyang He, Juewen Liu, Xiyun Yan, Kelong Fan   +4 more
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Poroptosis: A form of cell death depending on plasma membrane nanopores formation

iScience, 2022
Summary: Immunogenic cell death (ICD) in malignant cells can decrease tumor burden and activate antitumor immune response to obtain lasting antitumor immunity, leading to the elimination of distant metastases and prevention of recurrence. Here, we reveal
Hao Li, Zihao Wang, Xiaocui Fang, Wenfeng Zeng, Yanlian Yang, Lingtao Jin, Xiuli Wei, Yan Qin, Chen Wang, Wei Liang   +9 more
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Tuberculosis: Past, present and future of the treatment and drug discovery research

Current Research in Pharmacology and Drug Discovery, 2021
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug development and discovery against TB, it still leads among the causes of deaths due to infectious ...
Ameya D. Bendre, Peter J. Peters, Janesh Kumar   +2 more
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Large Oncosome‐Loaded VAPA Promotes Bone‐Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre‐Metastatic Niche

Advanced Science, 2022
Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment of distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis.
Shuxia Zhang, Xinyi Liao, Suwen Chen, Wanying Qian, Man Li, Yingru Xu, Meisongzhu Yang, Xincheng Li, Shuang Mo, Miaoling Tang, Xingui Wu, Yameng Hu, Ziwen Li, Ruyuan Yu, Ainiwaerjiang Abudourousuli, Libing Song, Jun Li   +16 more
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USP7 promotes non‐small‐cell lung cancer cell glycolysis and survival by stabilizing and activating c‐Abl

Clinical and Translational Medicine, 2023
Background Abelson tyrosine kinase (c‐Abl) is frequently mutated and highly expressed, and promotes non‐small‐cell lung cancer (NSCLC) survival, metastasis and tumorigenesis.
Yuanming He, Shuoyi Jiang, Yueya Zhong, Xiaoge Wang, Yaoli Cui, Jingpei Liang, Yuening Sun, Zhigang Zhu, Zhenqian Huang, Xinliang Mao   +9 more
doaj   +1 more source