Results 1 to 10 of about 7,902 (230)

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling [PDF]

BMC Cell Biology, 2008
Background Non-receptor tyrosine kinases (NTKs) regulate physiological processes such as cell migration, differentiation, proliferation, and survival by interacting with and phosphorylating a large number of substrates simultaneously.
Sharma Alok, Mayer Bruce J
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P130cas-FAK interaction is essential for YAP-mediated radioresistance of non-small cell lung cancer [PDF]

Cell Death and Disease, 2022
Based on the RNA-sequencing data, previous studies revealed that extracellular matrix receptor interaction and focal adhesion signaling pathways were enriched in radioresistant non-small cell lung cancer (NSCLC) cell lines.
Jingduo Li, Xiupeng Zhang, Zaiyu Hou, Siqi Cai, Yingxue Guo, Limei Sun, Ailin Li, Qingchang Li, Enhua Wang, Yuan Miao   +9 more
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p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands [PDF]

Scientific Reports, 2023
Salivary glands develop through epithelial-mesenchymal interactions and are formed through repeated branching. The Crk-associated substrate protein (p130Cas) serves as an adapter that forms a complex with various proteins via integrin and growth factor ...
Jing Gao, Aonan Li, Shinsuke Fujii, Fei Huang, Chihiro Nakatomi, Ichiro Nakamura, Hiroaki Honda, Tamotsu Kiyoshima, Eijiro Jimi   +8 more
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Cell Reports, 2021
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition.
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der   +36 more
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p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells

Breast Cancer: Targets and Therapy, 2009
Anna C Cunningham-Edmondson1,2, Steven K Hanks11Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, USAAbstract:
Anna C Cunningham-Edmondson, Steven K Hanks   +1 more
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Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation [PDF]

eLife
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz   +2 more
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The role of p130Cas/BCAR1 adaptor protein in the pathogenesis of cardiovascular diseases: A literature review [PDF]

American Heart Journal Plus
Breast cancer anti-estrogen resistance-1 (p130Cas/BCAR1) is an adaptor protein of the cas(Cas) family. This protein regulates multiple complex pathways in different organs including bones, pancreas, and immune and cardiovascular systems.
Ghazal Ghasempour Dabaghi, Mehrdad Rabiee Rad, Reza Amani-Beni, Bahar Darouei   +3 more
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CSRP2 promotes the glioblastoma mesenchymal phenotype via p130Cas-mediated NF-κB and MAPK pathways [PDF]

Journal of Experimental & Clinical Cancer Research
Background Cysteine-rich protein 2 (CSRP2) plays a role in a variety of biological processes including cell proliferation and differentiation. However, whether and how CSRP2 participates in the malignancy of glioblastoma multiforme (GBM), including its ...
Jiawei He, Liang Zhang, Hao Xu, Chengtian Gao, Wentao Zhao, Bingchang Zhang, Wanhong Han, Wenpeng Zhao, Guowei Tan, Sifang Chen, Ping Zhong, Zhe Shen, Jian Meng, Ziqian Tang, Hanwen Lu, Xin Gao, Zhangyu Li, Wenhua Li, Jianyao Mao, Bosen Liu, Yun-wu Zhang, Zhanxiang Wang   +21 more
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Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival.

PLoS ONE, 2014
Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular ...
Constantin Gonsior, Fabien Binamé, Carsten Frühbeis, Nina M Bauer, Peter Hoch-Kraft, Heiko J Luhmann, Jacqueline Trotter, Robin White   +7 more
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Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas [PDF]

BMC Biology, 2011
Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing
Anderson Kenneth C, Chauhan Dharminder
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