Results 11 to 20 of about 7,902 (230)

The interaction of p130Cas with PKN3 promotes malignant growth [PDF]

Molecular Oncology, 2019
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes ...
Jakub Gemperle, Michal Dibus, Lenka Koudelková, Daniel Rosel, Jan Brábek   +4 more
doaj   +5 more sources

Puromycin aminonucleoside modulates p130Cas of podocytes [PDF]

Korean Journal of Pediatrics, 2012
PurposePuromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers to
Tae-Sun Ha, Ji-Young Choi, Hye-Young Park   +2 more
doaj   +3 more sources

Endothelial p130cas confers resistance to anti-angiogenesis therapy [PDF]

Cell Reports, 2022
Summary: Anti-angiogenic therapies, such as anti-VEGF antibodies (AVAs), have shown promise in clinical settings. However, adaptive resistance to such therapies occurs frequently.
Yunfei Wen, Anca Chelariu-Raicu, Sujanitha Umamaheswaran, Alpa M. Nick, Elaine Stur, Pahul Hanjra, Dahai Jiang, Nicholas B. Jennings, Xiuhui Chen, Sara Corvigno, Deanna Glassman, Gabriel Lopez-Berestein, Jinsong Liu, Mien-Chie Hung, Anil K. Sood   +14 more
doaj   +5 more sources

p130Cas is an essential transducer element in ErbB2 transformation [PDF]

The FASEB Journal, 2010
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells. The functional role
Amici, A., Bisaro, B., Cabodi, S., Camacho-Leal, M. D., Cojoca, R., Defilippi, P., Di Stefano, P., Eva, A., Forni, G., Iezzi, M., Montani, M., Muthuswamy, S. K., Tarone, G., Tinnirello, A., Tornillo, G., Turco, E.   +15 more
core   +6 more sources

Immunohistochemical Study of the BCAR1/p130Cas Protein in Non-Malignant and Malignant Human Breast Tissue

The International Journal of Biological Markers, 2001
BCAR1/p130Cas is a docking protein involved in intracellular signaling pathways and in vitro resistance of estrogen-dependent breast cancer cells to antiestrogens.
S. van der Flier, T.H. van der Kwast, C.J.C. Claassen, M. Timmermans, A. Brinkman, S.C. Henzen-Logmans, J.A. Foekens, L.C.J. Dorssers   +7 more
doaj   +3 more sources

The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity [PDF]

Cell Communication and Signaling
Background Tongue squamous cell carcinoma (TSCC) is an aggressive cancer associated with a poor prognosis and limited treatment options, necessitating new drug targets to improve therapeutic outcomes.
Ali N. A. Hmedat, Jessica Doondeea, Daniel Ebner, Stephan M. Feller, Marc Lewitzky   +4 more
doaj   +2 more sources

RETRACTED ARTICLE: Epstein–Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma [PDF]

Nature Communications, 2015
Epstein–Barr virus (EBV), aetiologically linked to nasopharyngeal carcinoma (NPC), is the first human virus found to encode many miRNAs. However, how these viral miRNAs precisely regulate the tumour metastasis in NPC remains obscure.
Longmei Cai, Yanfen Ye, Qiang Jiang, Yuxiang Chen, Xiaoming Lyu, Jinbang Li, Shuang Wang, Tengfei Liu, Hongbing Cai, Kaitai Yao, Ji-Liang Li, Xin Li   +11 more
doaj   +2 more sources

P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration.

PLoS ONE, 2010
The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the leading edge plasma membrane.
Leslie M Meenderink, Larisa M Ryzhova, Dominique M Donato, Daniel F Gochberg, Irina Kaverina, Steven K Hanks   +5 more
doaj   +2 more sources

Regulation of p130Cas/BCAR1 Expression in Tamoxifen-Sensitive and Tamoxifen-Resistant Breast Cancer Cells by EGR1 and NAB2

Neoplasia: An International Journal for Oncology Research, 2012
Elevated levels of p130Cas/BCAR1 (Crk-associated substrate/breast cancer antiestrogen resistance 1) are found in aggressive breast tumors and are associated with tamoxifen resistance of mammary cancers.
Joerg Kumbrink, Kathrin H. Kirsch
doaj   +2 more sources

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease [PDF]

iScience
Summary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte ...
Casey R. Williamson, Claire E. Martin, J. Dinesh Kumar, Peihua Lu, Laura A. New, Alice Y. Wang, Nils M. Kronenberg, Malte C. Gather, Paul A. Reynolds, Nina Jones   +9 more
doaj   +2 more sources