HUBUNGAN ANTARA IMUNOEKSPRESI P130CAS DENGAN KARSINOMA TIROID PAPILARIS
Saintika Medika, 2012 Introduction: There are difficulties to determine follicular variants of papillary thyroid carcinomas if the pathological examination revealed no ground glass appearance in the nuclei/Orphan Annie eye, because the diagnosis of papillary thyroid ...
Mochamad Alex Sander
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A Role for p130Cas in Mechanotransduction [PDF]
Cell, 2006 Focal adhesions are sites of contact between cells and the extracellular matrix. Sawada et al. (2006) now report that the mechanical stretching of cells forces p130Cas, an adaptor protein at focal adhesions, to undergo a conformational change. This change promotes phosphorylation of p130Cas by Src family kinases and the transduction of integrin ...
Benjamin Geiger
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The docking protein p130Cas regulates cell sensitivity to proteasome inhibition [PDF]
BMC Biology, 2011 Background The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling pathways upon integrin or growth factor receptor ligation.
Vuori Kristiina, Zhao Ming
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Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus. [PDF]
Biotechnol BioengA cell‐sheet prepared from NIH 3T3 cells was sustained by a pair of glass microneedles above a glass‐bottom dish under the spinning disc confocal microscope equipped with a dual‐view system (left). The cell‐sheet was mechanically stretched by moving one of the microneedles away from the other and the locations of proteins related to focal adhesion were
Suzuki M +5 more
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Endothelial p130cas confers resistance to anti-angiogenesis therapy [PDF]
Cell Reports, 2023 Yunfei Wen +14 more
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The p130Cas-Crk/CrkL Axis: A Therapeutic Target for Invasive Cancers Unveiled by Collaboration Among p130Cas, Crk, and CrkL. [PDF]
Int J Mol SciNumerous studies have documented the involvement of p130Cas (Crk-associated substrate) in a wide range of cellular processes across different types of cells. These processes encompass cell transformation, the connection between the extracellular matrix and the actin cytoskeleton, cell migration and invasion, and cardiovascular development.
Farhadi P, Park T.
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p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer?
Frontiers in Cell and Developmental Biology, 2021 p130Cas/BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity, whose modular structure with various binding motifs, allows the formation of multi-protein signaling complexes.
Giorgia Centonze +5 more
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P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation. [PDF]
PLoS ONE, 2011 BACKGROUND: Endocytosis controls localization-specific signal transduction via epidermal growth factor receptor (EGFR), as well as downregulation of that receptor. Extracellular matrix (ECM)-integrin coupling induces formation of macromolecular complexes
Yong Seok Kang +5 more
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Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis. [PDF]
Methods EnzymolDouglas JT, Johnson DK, Roy A, Park T.
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Targeting Tn Antigen Suppresses Aberrant O-Glycosylation-Elicited Metastasis in Breast Cancer. [PDF]
J Cell Mol MedABSTRACT The Tn antigen, a truncated O‐glycan representing aberrant mucin‐type O‐glycosylation, is frequently observed in human breast cancer. However, the functional role of Tn antigen in breast cancer metastasis remains insufficiently investigated. This study aimed to elucidate the expression profile of Tn antigen in breast cancer and its potential ...
Du T +6 more
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