Results 51 to 60 of about 7,902 (230)

VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy- Terminal NRP1 Fragments That Regulate Angiogenic Signaling [PDF]

, 2018
OBJECTIVE: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism
Evans, I M, Field, L, Jones, T, Mahmoud, M, Mehta, V, Pellet-Many, C, Yamaji, M, Zachary, I   +7 more
core   +3 more sources

Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes. [PDF]

PLoS ONE, 2014
Focal adhesion kinase (FAK) plays an important role in signal transduction pathways initiated at sites of integrin-mediated cell adhesion to the extracellular matrix.
Thérèse B Deramaudt, Denis Dujardin, Fanny Noulet, Sophie Martin, Romain Vauchelles, Ken Takeda, Philippe Rondé   +6 more
doaj   +1 more source

Neuropilins: Role in Signalling, Angiogenesis and Disease [PDF]

, 2013
Neuropilins (NRPs) are co-receptors for class 3 semaphorins and for members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines.
Zachary, I
core   +1 more source

Ibuprofen inhibited migration of skeletal muscle cells in association with downregulation of p130cas and CrkII expressions

Skeletal Muscle, 2019
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat sports-related muscle injuries. However, NSAIDs were recently shown to impede the muscle healing process after acute injury.
Chih-Hao Liao, Li-Ping Lin, Tung-Yang Yu, Chih-Chin Hsu, Jong-Hwei S. Pang, Wen-Chung Tsai   +5 more
doaj   +1 more source

Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

eLife, 2022
Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate initial IAC formation are unclear.
Lindsay B Case, Milagros De Pasquale, Lisa Henry, Michael K Rosen   +3 more
doaj   +1 more source

p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion [PDF]

, 2014
Oncogenic Ras induces cell transformation and promotes an invasive phenotype. The tumor suppressor p53 has a suppressive role in Rasdriven invasion. However, its mechanism remains poorly understood.
Ai Kia Yip, Akin, Albini, Alvin Kunyao Guo, Cabodi, Campbell, Cheng-han Yu, De Vos, Defilippi, Enoksson, Fantin, Gilmore, Green, Grethe, Guo, Hiroaki Hirata, Hoshino, Hu, Ichiro Harada, Johansson, Kawauchi, Kawauchi, Keiko Kawauchi, Keil, Keng-Hwee Chiam, Kiuchi, Kong, Liu, Marabese, Martinou, Meek, Miyashita, Moore, Muller, Nakano, Nobuyuki Tanaka, Olson, O’Keefe, Parsons, Pawlak, Perumalsamy, Petrie, Plun-Favreau, Riedl, Rivlin, Sakai, Sharma, Sherr, Shota Yamauchi, Su, Suzuki, Tait, Vande Walle, Vande Walle, Vaseva, Vaseva, Vousden, Vuori, Wang, Wataru Nakajima, Westermann, Yamasaki, Yan Yan Hou, Yasuhiro Sawada, Yip, Zheng   +65 more
core   +2 more sources

Modeling ErbB2-p130Cas interaction to design new potential anticancer agents [PDF]

Scientific Reports, 2019
AbstractThe ErbB2 receptor tyrosine kinase is overexpressed in approximately 15–20% of breast tumors and associated with aggressive disease and poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration and proliferation in normal and pathological contexts.
Andrea Costamagna, Matteo Rossi Sebastiano, Dora Natalini, Matilde Simoni, Giorgio Valabrega, Paola Defilippi, Sonja Visentin, Giuseppe Ermondi, Emilia Turco, Giulia Caron, Sara Cabodi   +10 more
openaire   +3 more sources

Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold [PDF]

, 2004
The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary conserved signaling module that controls cell proliferation, survival and migration.
Schwartz, Schlaepfer, Klemke, Takino, Cho, Takino, Reddien, Kain, Reddien, Gumienny, Miller, Feller, Feller, Kiyokawa, Mayer, Schlessinger, Pawson, Mayer, Prosser, Rosen, Donaldson, ten Hoeve, Songyang, Turner, Panetti, Schaller, Schaller, Bouton, Stupack, Sakai, Smit, Liu, Thien, Rao, Chin, Ota, Liu, Hibi, Casamassima, Gelkop, Coggeshall, March, Rohrschneider, Knudsen, Posern, Buensuceso, Gotoh, Tanaka, Kiyokawa, Nishihara, Feller, Feller, Ren, Smith, Van Etten, Nimnual, Schumacher, Confalonieri, Salcini, Mochizuki, Girardin, Smith, Galletta, Li, Arai, Law, Ishino, Alexandropoulos, Nakamoto, Law, Minegishi, Nakamoto, Polte, Vuori, Nojima, Cheresh, Cary, Hanks, Cary, Lakkakorpi, Astier, Garton, Liu, Li, Nakashima, Petch, Owen, Ruest, Sakai, Schlaepfer, Vuori, Fonseca, Goldberg, Garton, Mielenz, Gu, Manie, Kiyokawa, Grimsley, Wymann, Hawkins, Yokote, Ojaniemi, Casamassima, Liu, Kook, Van Etten, Raitano, Shishido, Plattner, Lamorte, Riordan, Kirsch, Schlaepfer, Prasad, Garcia-Guzman, Abassi, Ting, Hashimoto, Cho, Hamasaki, Kiosses, Brahmbhatt, Bailly, Chodniewicz, Chodniewicz, Bokel, Pendergast, Kruh, Wang, Woodring, Koleske, Lanier, Lewis, Lewis, Wang, Kain, Frasca, Lamorte, Chen, Wells, Renshaw, Zvara, Vuori, Dolfi, Woodring, Pellicena, Steller, Raff, Testaz, Barila, Sieg, Yuan, Gong, Fogerty, Kolibaba, Rhodes, Iwahara, Matsuda, Honda, van der Flier, Spencer, Bruce-Staskal, Goel   +163 more
core   +1 more source

Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules

Redox Biology, 2014
Shifts in intracellular Reactive Oxygen Species (ROS) have been shown to contribute to carcinogenesis and to tumor progression. In addition to DNA and cell damage by surges in ROS, sub-lethal increases in ROS are implicated in regulating cellular ...
Nadine Hempel, J. Andres Melendez
doaj   +1 more source

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells [PDF]

, 2000
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of
Brinkman, A. (Arend), Dorssers, L.C.J. (Lambert), Flier, S. (Silvia) van der, Kok, E.M. (Elisabeth)   +3 more
core   +2 more sources