Radioligands Targeting the Purinergic P2X Receptors [PDF]
CellsPurinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben +7 more
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Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists [PDF]
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
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Zhongguo dianli, 2021 As a cutting-edge technological concept, P2X represents the conversion of electrical energy to heat, cold, gas and other forms of energy. Based on the basic concept of P2X, this paper reviews the P2X technology system, evaluates the economics and ...
Ning ZHANG +5 more
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P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]
PLoS ONE, 2013 We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung +7 more
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Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. [PDF]
PLoS ONE, 2009 Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes.
Virginie F Labrousse +6 more
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Direct observation of ATP-induced conformational changes in single P2X(4) receptors. [PDF]
PLoS Biology, 2009 The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood.
Youichi Shinozaki +5 more
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Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. [PDF]
PLoS ONE, 2011 Improper wound repair of the corneal epithelium can alter refraction of light resulting in impaired vision. We have shown that ATP is released after injury, activates purinergic receptor signaling pathways and plays a major role in wound closure. In many
Courtney Mankus +3 more
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Offshore Wind Power Integration into Future Power Systems: Overview and Trends
Journal of Marine Science and Engineering, 2019 Nowadays, wind is considered as a remarkable renewable energy source to be implemented in power systems. Most wind power plant experiences have been based on onshore installations, as they are considered as a mature technological solution by the ...
Ana Fernández-Guillamón +3 more
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Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats
Molecular Pain, 2006 Extracellular ATP is known to mediate synaptic transmission as a neurotransmitter or a neuromodulator via ionotropic P2X and metabotropic P2Y receptors.
Satoh Masamichi +4 more
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A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family. [PDF]
PLoS ONE, 2012 Phosphoinositides modulate the function of several ion channels, including most ATP-gated P2X receptor channels in neurons and glia, but little is known about the underlying molecular mechanism.
Louis-Philippe Bernier +3 more
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