Results 1 to 10 of about 19,677 (253)
Recommended tool compounds and drugs for blocking P2X and P2Y receptors [PDF]
Purinergic Signalling Purinergic Signalling, 2021 This review article presents a collection of tool compounds that selectively block and are recommended for studying P2Y and P2X receptor subtypes, investigating their roles in physiology and validating them as future drug targets.
C. Müller, V. Namasivayam
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2016 Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y receptors. P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. In molecular architecture, they form a unique structural family.
R. North
semanticscholar +3 more sources
To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?
Frontiers in Pharmacology, 2020 The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and ...
Leanne Stokes +3 more
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The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors [PDF]
Frontiers in Pharmacology, 2018 P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP—their physiological ligand—is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X receptors in ...
Gaia Pasqualetto, A. Brancale, M. Young
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Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor [PDF]
PharmaceuticalsP2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to the ...
Jonathas Albertino De Souza Oliveira Carneiro +3 more
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Radioligands Targeting the Purinergic P2X Receptors [PDF]
CellsPurinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben +7 more
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Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel
eLife, 2016 P2X receptors function by opening a transmembrane pore in response to extracellular ATP. Recent crystal structures solved in apo and ATP-bound states revealed molecular motions of the extracellular domain following agonist binding. However, the mechanism
C. Habermacher +7 more
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P2X receptor channels in chronic pain pathways [PDF]
British Journal of Pharmacology, 2018 L. Bernier, A. Ase, P. Séguéla
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Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
Neural Plasticity, 2017 Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia.
Eric Boué-Grabot, Yuriy Pankratov
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P2X receptors and acupuncture analgesia
Brain Research Bulletin, 2019 Purinergic signaling has recently been suggested to constitute the cellular mechanism underlying acupuncture-induced analgesia (AA). By extending the original hypothesis on endogenous opioids being released during AA, Geoffrey Burnstock and Maiken Nedergaard supplied evidence for the involvement of purinoceptors (P2 and P1/A1 receptors) in the ...
Yong Tang +4 more
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