Results 11 to 20 of about 39,255 (248)
The trafficking and targeting of P2X receptors [PDF]
Frontiers in Cellular Neuroscience, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties.
Lucy E. Robinson +1 more
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Cytolytic P2X purinoceptors [PDF]
Cell Death & Differentiation, 1998 Anecdoctal evidence accumulated over almost 20 years has shown that many different cell types are killed by sustained exposure to high concentrations of extracellular ATP. The plasma membrane receptors involved have been pharmacologically characterized and cloned during the last 3 years, and named purinergic P2X.
DI VIRGILIO, Francesco +6 more
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P2X receptors in neuroglia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A. +3 more
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Heteromeric assembly of P2X subunits [PDF]
Frontiers in Cellular Neuroscience, 2013 Published by Frontiers Research Foundation ...
Ralf Hausmann +4 more
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P2X receptors in sensory neurones
British Journal of Anaesthesia, 2000 P2X receptors are a family of ligand-gated ion channels responsive to ATP. Seven subtypes have been identified which form homo-multimeric or hetero-multimeric pores. P2X3 receptors are selectively expressed predominantly on small-diameter nociceptive sensory neurones in the dorsal root, trigeminal and nodose ganglia, particularly the non-peptidergic ...
G. Burnstock
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Current Biology, 2004 What are they? P2X channels are a family of cell-membrane cation channels which open within milliseconds of binding ATP. They are distinct from the other family of ATP receptors, the G-protein-coupled P2Y receptors, and also from other transmitter-gated ion channels.
Baljit S. Khakh, Gemma C. Girdler
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2016 Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y receptors. P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. In molecular architecture, they form a unique structural family.
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Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]
, 2000 Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G +5 more
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An evolutionary history of P2X receptors [PDF]
Purinergic Signalling, 2008 Adenosine triphosphate (ATP) is an ancient and fundamentally important biological molecule involved in both intracellular and extracellular activities. P2X ionotropic and P2Y metabotropic receptors have been cloned and characterised in mammals. ATP plays a central physiological role as a transmitter molecule in processes including the sensation of pain,
Fountain, Samuel J., Burnstock, Geoffrey
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Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]
, 1998 Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L. +13 more
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