Results 11 to 20 of about 19,677 (253)
Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels
Cell Reports, 2016 P2X receptors are trimeric ATP-gated cation channels involved in physiological processes ranging widely from neurotransmission to pain and taste signal transduction. The modulation of the channel gating, including that by divalent cations, contributes to
Go Kasuya +7 more
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Pharmacology of P2X Receptors and Their Possible Therapeutic Potential in Obesity and Diabetes [PDF]
PharmaceuticalsThe role of P2X ionotropic receptors in the behavior of purinergic signaling on pathophysiological processes has been widely studied. In recent years, the important participation of P2X receptors in physiological and pathological processes, such as ...
Guillermo A. Cabral-García +5 more
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Zhongguo dianli, 2021 As a cutting-edge technological concept, P2X represents the conversion of electrical energy to heat, cold, gas and other forms of energy. Based on the basic concept of P2X, this paper reviews the P2X technology system, evaluates the economics and ...
Ning ZHANG +5 more
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P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]
PLoS ONE, 2013 We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung +7 more
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Cytolytic P2X purinoceptors [PDF]
Cell Death & Differentiation, 1998 Anecdoctal evidence accumulated over almost 20 years has shown that many different cell types are killed by sustained exposure to high concentrations of extracellular ATP. The plasma membrane receptors involved have been pharmacologically characterized and cloned during the last 3 years, and named purinergic P2X.
DI VIRGILIO, Francesco +6 more
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Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. [PDF]
PLoS ONE, 2009 Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes.
Virginie F Labrousse +6 more
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Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
British Journal of Pharmacology, 2020 The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting of two transmembrane regions (TM1 and TM2), intracellular N‐ and C‐termini, and ...
P. Illés +11 more
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Direct observation of ATP-induced conformational changes in single P2X(4) receptors. [PDF]
PLoS Biology, 2009 The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood.
Youichi Shinozaki +5 more
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Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. [PDF]
PLoS ONE, 2011 Improper wound repair of the corneal epithelium can alter refraction of light resulting in impaired vision. We have shown that ATP is released after injury, activates purinergic receptor signaling pathways and plays a major role in wound closure. In many
Courtney Mankus +3 more
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Energy Conversion and Management: X, 2023 For achieving a carbon–neutral energy system, economical flexibility mechanisms are crucial to accommodate intermittent and decentralized renewable energy sources. Power-to-X (P2X) is a promising technology for this purpose.
Hiroaki Onodera +2 more
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