Results 21 to 30 of about 39,255 (248)

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

A P2X receptor from the tardigrade species Hypsibius dujardini with fast kinetics and sensitivity to zinc and copper

BMC Evolutionary Biology, 2009
Background Orthologs of the vertebrate ATP gated P2X channels have been identified in Dictyostelium and green algae, demonstrating that the emergence of ionotropic purinergic signalling was an early event in eukaryotic evolution.
Blaxter Mark L, Straub Volko A, Bavan Selvan, Ennion Steven J   +3 more
doaj   +1 more source

P2X receptor signaling inhibits BDNF-mediated spiral ganglion neuron development in the neonatal rat cochlea. [PDF]

, 2007
Type I and type II spiral ganglion neurons (SGN) innervate the inner and outer hair cells of the cochlea, respectively. This neural system is established by reorganization of promiscuous innervation of the hair cells, immediately before hearing is ...
Auckland, Sydney, California San Diego, Greenwood, D, Housley, G D, Hoya, N, Huang, L C, Jagger, D J, King, B F, Pak, K, Ryan, A F, Thorne, P R, UCL, Wildman, S S   +12 more
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ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
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Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

Molecular Neurodegeneration, 2011
Background Previous studies indicate a role of P2X7 receptors in processes that lead to neuronal death. The main objective of our study was to examine whether genetic deletion or pharmacological blockade of P2X7 receptors influenced dopaminergic cell ...
Kittel Ágnes, Madarász Emilia, Gölöncsér Flóra, Csölle Cecilia, Baranyi Mária, Hracskó Zsuzsanna, Sperlágh Beáta   +6 more
doaj   +1 more source

Activation of P2X₇-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice

BMC Cancer, 2009
Background The study tested the hypothesis that apoptosis can prevent and control growth of neoplastic cells. Previous studies in-vitro have shown that the pro-apoptotic P2X7 receptor regulates growth of epithelial cells.
Fu Wen, McCormick Tom, Qi Xiaoping, Luo Liping, Zhou Lingyin, Li Xin, Wang Bing-Cheng, Gibbons Heidi E, Abdul-Karim Fadi W, Gorodeski George I   +9 more
doaj   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank, Lalo, Ulyana, North, R. Alan, Pankratov, Yuriy, Rossner, Moritz J., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), Wichert, Sven P.   +6 more
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Research progress in the role of P2X receptors in oral maxillofacial pain

口腔疾病防治, 2018
Oral maxillofacial pain is one of the most common symptoms that greatly influences patients′ quality of life. Infectious diseases, nerve injuries and tumors in the oromaxillofacial region can cause facial pain.
HE Lingkun, XIONG Wei
doaj   +1 more source

To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

Frontiers in Pharmacology, 2020
The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and ...
Leanne Stokes, Stefan Bidula, Lučka Bibič, Elizabeth Allum   +3 more
doaj   +1 more source