Results 1 to 10 of about 12,622 (95)

Serum P2X7 as a prognostic biomarker in acute supratentorial intracerebral hemorrhage: a two-center observational study [PDF]

Frontiers in Neurology
IntroductionP2X7 participates in neuroinflammation underlying acute brain injury. In this study, we investigated the prognostic role of serum P2X7 in acute intracerebral hemorrhage (ICH).MethodsThis two-center observational analytic study enrolled 95 ...
Xinle Chen, Hao Shan, Tiancheng Lu, Boren Zheng, Xiaoqiao Dong, Yulin Sun, Xiaojun Zhong, Guozheng Ying   +7 more
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Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation [PDF]

eLife
ATP-gated purinergic P2X7 receptors are crucial ion channels involved in inflammation. They sense abnormal ATP release during stress or injury and are considered promising clinical targets for therapeutic intervention.
Benoit Arnould, Adeline Martz, Pauline Belzanne, Francisco Andrés Peralta, Federico Cevoli, Volodya Hovhannisyan, Yannick Goumon, Eric Hosy, Alexandre Specht, Thomas Grutter   +9 more
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ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway [PDF]

Frontiers in Immunology
BackgroundDuring cerebral ischemia, adenosine triphosphate (ATP) is released into the extracellular matrix from damaged neurons and glial cells, functioning as a danger signal.
Wenying Liu, Wenying Liu, Denghui Li, Mengjie Zhang, Jun Yin, Peng Wang, Paiyu Liu, Zhiqiang Song, Bing Ni, Yanmeng Peng   +9 more
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Macrophage expression of P2X7 controls autoimmune uveitis [PDF]

Journal of Neuroinflammation
The release of danger-associated molecular patterns (DAMPs) such as ATP from stressed or damaged cells is a key initiator of sterile inflammation. In autoimmune diseases, extracellular ATP acts as a potent pro-inflammatory signal by activating the ...
Paul-Alexandre Déchelle-Marquet, Yueshen Che, Camille Roux, Frédéric Blond, Kaitryn E. Ronning, Sébastien Augustin, Pauline Lagouge-Roussey, Caroline Nous, Sara Touhami, Bahram Bodaghi, Jean Kanellopoulos, Sahil Adriouch, Xavier Guillonneau, Florian Sennlaub, Cécile Delarasse   +14 more
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P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: Role of the A2A/CD39/CD73 axis [PDF]

Cell Death and Disease
Extracellular vesicle-driven cancer metastasis represents a therapeutic challenge due to the lack of effective blocking drugs. Our study shows that activation of the P2X7 receptor on colon carcinoma cells causes the release of vesicles carrying CD39 and ...
Anna Pegoraro, Elena De Marchi, Luigia Ruo, Michele Zanoni, Sofia Chioccioli, Giovanna Caderni, Letizia Alfieri, Marianna Grignolo, Paola Ulivi, Alessandro Passardi, Graziana Gallo, Luca Antonioli, Francesco Di Virgilio, Elena Adinolfi   +13 more
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Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs

Frontiers in Pharmacology, 2022
The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation.
Carolina Pinto-Espinoza, Carolina Pinto-Espinoza, Charlotte Guillou, Björn Rissiek, Maximilian Wilmes, Ehsan Javidi, Nicole Schwarz, Nicole Schwarz, Marten Junge, Friedrich Haag, Nastassia Liaukouskaya, Nicola Wanner, Annette Nicke, Catelijne Stortelers, Yossan-Var Tan, Sahil Adriouch, Tim Magnus, Friedrich Koch-Nolte   +17 more
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P2X7 receptor in inflammation and pain

Brain Research Bulletin, 2022
Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key role in the development of pain. P2X7 receptor activation can induce the development of pain by mediating the release of inflammatory mediators. In view of the fact
Shi-qi Hu, Jia-ling Hu, Fei-long Zou, Ji-peng Liu, Hong-liang Luo, Dong-xia Hu, Li-dong Wu, Wen-jun Zhang   +7 more
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P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

Frontiers in Pharmacology, 2020
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio, Shaun McNulty   +6 more
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P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles

Frontiers in Pharmacology, 2022
Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin M. H. Rumney, Justyna Róg, Natalia Chira, Alexander P. Kao, Rasha Al-Khalidi, Dariusz C. Górecki, Dariusz C. Górecki   +6 more
doaj   +1 more source

P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice

Frontiers in Molecular Neuroscience, 2020
The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell death, neuronal plasticity and the release of neurotransmitters.
Giorgia Conte, Ngoc T. Nguyen, Ngoc T. Nguyen, Mariana Alves, Laura de Diego-Garcia, Aidan Kenny, Annette Nicke, David C. Henshall, David C. Henshall, Eva M. Jimenez-Mateos, Tobias Engel, Tobias Engel   +11 more
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