Results 11 to 20 of about 12,691 (159)
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions [PDF]
Journal of Neuroinflammation, 2022 Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases.
Maximilian Wilmes +14 more
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P2X7 Receptor in Hematological Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 The P2X7 receptor is an ion channel gated by the nucleotide ATP, known for its role in immune responses and recently emerging as a critical onco-promoting factor.
Elena De Marchi +2 more
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P2X7 Variants in Oncogenesis [PDF]
Cells, 2021 The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies.
Anna Pegoraro +2 more
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The P2X7 Receptor in Osteoarthritis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is the most common joint disease. With the increasing aging population, the associated socio-economic costs are also increasing. Analgesia and surgery are the primary treatment options in late-stage OA, with drug treatment only possible in early prevention to improve patients’ quality of life. The most important structural component
Zihao Li, Ziyu Huang, Lunhao Bai
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Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses [PDF]
Journal of Leukocyte Biology, 2009 AbstractThe purinergic receptor P2X7 is expressed on immune cells, and its stimulation results in the release of IL-1β from macrophages. Its absence, as evidenced from the analysis of two independent strains of P2X7-deficient mice, results in reduced susceptibility to inflammatory disease, and the molecule is an important, potential therapeutic target ...
Taylor, SRJ +8 more
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The P2X7 Receptor in Tumor Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair.
Fabio Grassi +2 more
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Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation. [PDF]
PLoS ONE, 2012 P2X7 is a homotrimeric ion channel with two transmembrane domains and a large extracellular ATP-binding domain. It plays a key role in the response of immune cells to danger signals released from cells at sites of inflammation.
Nicole Schwarz +8 more
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The P2X7 Receptor in Autoimmunity
International Journal of Molecular Sciences, 2023 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues.
Fabio Grassi, Gaia Salina
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تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]
مجله دانشکده پزشکی اصفهانمقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعهی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئینهای Pannexin-1، P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 میباشد.روشها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفتهای از نژاد ...
یاسمن رفیعی +3 more
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The role of microglial P2X7: modulation of cell death and cytokine release
Journal of Neuroinflammation, 2017 Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He +3 more
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