Results 21 to 30 of about 12,691 (159)

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3

Haematologica, 2020
Nucleotides mediate intercellular communication by activating purinergic receptors and take part in various physiological and pathological processes. Abnormal purinergic signaling plays important roles in malignant progression. P2X7, which belongs to the
Wenli Feng, Xiao Yang, Lina Wang, Rong Wang, Feifei Yang, Hao Wang, Xiaoli Liu, Qian Ren, Yingchi Zhang, Xiaofan Zhu, Guoguang Zheng   +10 more
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Radioligands targeting purinergic P2X7 receptor [PDF]

Bioorganic & Medicinal Chemistry Letters, 2020
The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target.
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Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors [PDF]

Journal of Biological Chemistry, 2003
The purinergic P2X7 receptor not only gates the opening of a cationic channel, but also couples to several downstream signaling events such as rapid membrane blebbing, microvesicle shedding, and interleukin-1beta release. Protein-protein interactions are likely to be involved in most of these signaling cascades; and recently, a P2X7 receptor-protein ...
ADINOLFI, Elena, KIM M, YOUNG MT, DI VIRGILIO, Francesco, SURPRENANT A.   +4 more
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Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

Frontiers in Pharmacology, 2018
The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction.
Anindya Bhattacharya
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Dissecting activation steps in P2X7 receptors

Biochemical and Biophysical Research Communications, 2021
P2X7 receptors are trimeric ion channels activated by extracellular ATP. Upon activation, they trigger cytolysis and apoptosis but also control cell proliferation. To shed more light on channel gating and the underlying function of the individual subunits, receptors of concatenated subunits were built containing a defined number of functional binding ...
Milica Gusic, Klaus Benndorf, Christian Sattler   +2 more
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Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model

Journal of Inflammation Research, 2022
Moumita Saha,1 Krishnendu Manna,2 Krishna Das Saha1 1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India; 2Department of Food and Nutrition, University of Kalyani, Kalyani, West Bengal,
Saha M, Manna K, Das Saha K
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The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity [PDF]

Journal of Biological Chemistry, 2008
P2X(7) receptors are ATP-gated cation channels composed of three identical subunits, each having intracellular amino and carboxyl termini and two transmembrane segments connected by a large ectodomain. Within the P2X family, P2X(7) subunits are unique in possessing an extended carboxyl tail.
Daniel, Becker, Ronja, Woltersdorf, Wolfgang, Boldt, Stephan, Schmitz, Ursula, Braam, Günther, Schmalzing, Fritz, Markwardt   +6 more
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Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

eLife, 2018
The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number of studies suggest its presence in neurons where its putative functions remain controversial for more than a decade.
Karina Kaczmarek-Hajek, Jiong Zhang, Robin Kopp, Antje Grosche, Björn Rissiek, Anika Saul, Santina Bruzzone, Tobias Engel, Tina Jooss, Anna Krautloher, Stefanie Schuster, Tim Magnus, Christine Stadelmann, Swetlana Sirko, Friedrich Koch-Nolte, Volker Eulenburg, Annette Nicke   +16 more
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The P2X7 Receptor-Interleukin-1 Liaison [PDF]

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies, such as type II diabetes, gout and atherosclerosis.
GIULIANI, Anna Lisa, SARTI, Alba Clara, FALZONI, Simonetta, DI VIRGILIO, Francesco   +3 more
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Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.

PLoS ONE, 2012
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
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