Results 31 to 40 of about 12,691 (159)

P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity of Toxoplasma gondii-Induced Ileitis

Biomedicines, 2023
In mice, oral Toxoplasma gondii infection induces severe ileitis. The aim of the present study was to investigate the impact of the P2X7 receptor (P2X7) on the inflammatory response to T. gondii-induced ileitis. Cysts of the ME49 strain of T. gondii were
Aline Cristina Abreu Moreira-Souza, Hayandra Ferreira Nanini, Thuany Prado Rangel, Sthefani Rodrigues Batista da Silva, Beatriz Pêgo Damasceno, Beatriz Elias Ribeiro, Cynthia M. Cascabulho, Fabiano Thompson, Camille Leal, Patrícia Teixeira Santana, Siane Lopes Bittencourt Rosas, Kívia Queiroz de Andrade, Claudia L. Martins Silva, Rossiane Claudia Vommaro, Heitor Siffert Pereira de Souza, Robson Coutinho-Silva   +15 more
doaj   +1 more source

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors [PDF]

British Journal of Pharmacology, 2009
Background and purpose: Acute activation of P2X7 receptors rapidly opens a non‐selective cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surface.
Diana L, Donnelly-Roberts, Marian T, Namovic, Ping, Han, Michael F, Jarvis   +3 more
openaire   +2 more sources

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist

Biomolecules, 2022
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter   +12 more
doaj   +1 more source

The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review

Brain Circulation
BACKGROUND: When a seizure occurs, the distribution of purine receptors in different cell types at various time points remains poorly understood. Our literature review revealed that P2X7, P2Y6, and P2Y12 are expressed in different cells during epilepsy ...
Yue Li, Fengru Tang, Yumin Luo
doaj   +1 more source

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

Frontiers in Neuroscience, 2019
The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717.
Melissa Crabbé, Melissa Crabbé, Anke Van der Perren, Anke Van der Perren, Ilse Bollaerts, Savannah Kounelis, Savannah Kounelis, Veerle Baekelandt, Veerle Baekelandt, Veerle Baekelandt, Guy Bormans, Guy Bormans, Cindy Casteels, Cindy Casteels, Lieve Moons, Lieve Moons, Koen Van Laere, Koen Van Laere   +17 more
doaj   +1 more source

P2X7 mediates ATP-driven invasiveness in prostate cancer cells. [PDF]

PLoS ONE, 2014
The ATP-gated P2X7 has been shown to play an important role in invasiveness and metastasis of some tumors. However, the possible links and underlying mechanisms between P2X7 and prostate cancer have not been elucidated.
Ying Qiu, Wei-Hua Li, Hong-Quan Zhang, Yan Liu, Xin-Xia Tian, Wei-Gang Fang   +5 more
doaj   +1 more source

The P2X7 Receptor: Central Hub of Brain Diseases

Frontiers in Molecular Neuroscience, 2020
The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the ...
Roberta Andrejew, Ágatha Oliveira-Giacomelli, Deidiane Elisa Ribeiro, Talita Glaser, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu, Henning Ulrich   +6 more
doaj   +1 more source

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits

Frontiers in Pharmacology, 2017
P2X4 and P2X7 are members of the P2X receptor family, comprising seven isoforms (P2X1–P2X7) that form homo- and heterotrimeric non-specific cation channels gated by extracellular ATP.
Markus Schneider, Kirsten Prudic, Anja Pippel, Manuela Klapperstück, Ursula Braam, Christa E. Müller, Günther Schmalzing, Fritz Markwardt   +7 more
doaj   +1 more source

A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization [PDF]

Journal of Biological Chemistry, 2006
A truncated naturally occurring variant of the human receptor P2X7 was identified in cancer cervical cells. The novel protein (P2X7-j), a polypeptide of 258 amino acids, lacks the entire intracellular carboxyl terminus, the second transmembrane domain, and the distal third of the extracellular loop of the full-length P2X7 receptor.
Ying-Hong, Feng, Xin, Li, Liqin, Wang, Lingying, Zhou, George I, Gorodeski   +4 more
openaire   +2 more sources

P2X7 Variants in Pathophysiology

International Journal of Molecular Sciences
P2X7 receptor activation by extracellular adenosine triphosphate (eATP) modulates different intracellular pathways, including pro-inflammatory and tumor-promoting cascades. ATP is released by cells and necrotic tissues during stressful conditions and accumulates mainly in the inflammatory and tumoral microenvironments.
Pegoraro A., Grignolo M., Ruo L., Ricci L., Adinolfi E.   +4 more
openaire   +3 more sources