Results 71 to 80 of about 12,691 (159)
Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.ABSTRACT Background Zika virus (ZIKV) is a flavivirus that has gained global attention due to its association with congenital microcephaly and neuroinflammatory responses. Markers of endothelial activation and purinergic signaling have been identified in the context of ZIKV neuropathogenesis, although the underlying mechanisms remain poorly understood.
Jorge Rodrigues de Sousa +12 more
wiley +1 more source
Sex Differences in Metabolite–Immune Circuits of Neuroinflammation
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan +6 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2000 The expression of P2Z/P2X7 purinoceptor in different cell types is well established. This receptor is a member of the ionotropic P2X receptor family, which is composed by seven cloned receptor subtypes (P2X1 - P2X7).
Nihei Oscar Kenji +2 more
doaj
P2x7 receptors control demyelination and inflammation in the cuprizone model
Brain, Behavior, & Immunity - Health, 2020 The contribution of P2x7 receptors to multiple sclerosis remains controversial, as both detrimental and beneficial effects resulting from P2x7 receptor loss-of-function have been reported in autoimmune models of the disease.
Ana Bernal-Chico +5 more
doaj +1 more source
P2X7 Forges Ahead in Neonatal Hypoxia
Epilepsy Currents, 2023 [Box: see text]
openaire +2 more sources
Journal of Neurochemistry, Volume 170, Issue 3, March 2026.Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad +5 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez +11 more
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Astrocyte Regulation of Spinal Circuit Function
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff +2 more
wiley +1 more source
P2X7 blockade attenuates mouse liver fibrosis
Molecular Medicine Reports, 2013 P2X7 is important in inflammation and tissue injury. The aim of the present study was to investigate the effect of P2X7 inhibition, using a specific inhibitor (A438079) to prevent the development of liver injury and fibrosis in a mouse model of liver fibrosis. The mouse liver fibrosis model was induced by carbon tetrachloride (CCl4).
Changshan, Huang +6 more
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