Results 81 to 90 of about 12,691 (159)

Ion channel P2X7 receptor in the progression of cancer

Frontiers in Oncology
P2X7 receptor (P2X7) is a non-selective and ATP-sensitive ligand-gated cation channel. Studies have confirmed that it is expressed in a variety of cells and correlates with their function, frequently in immune cells and tumor cells.
Guang-ping Zhang, Guang-ping Zhang, Jun-xiang Liao, Yi-yi Liu, Fu-qi Zhu, Hui-jin Huang, Wen-jun Zhang   +6 more
doaj   +1 more source

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

JCI Insight, 2021
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease.
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir N.P. Kelada, Stephen L. Tilley   +18 more
doaj   +1 more source

Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1

Mediators of Inflammation, 2014
Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role ...
Suellen D’arc Santos Oliveira, Hayandra Ferreira Nanini, Luiz Eduardo Baggio Savio, Mariana Caldas Waghabi, Claudia Lucia Martins Silva, Robson Coutinho-Silva   +5 more
doaj   +1 more source

P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Frontiers in Immunology, 2017
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain ...
Maria Barberà-Cremades, Ana I. Gómez, Alberto Baroja-Mazo, Laura Martínez-Alarcón, Carlos M. Martínez, Carlos de Torre-Minguela, Pablo Pelegrín   +6 more
doaj   +1 more source

Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4.

PLoS Pathogens, 2019
Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. P2X7 receptor has been linked to the elimination of Leishmania amazonensis.
Mariana M Chaves, Debora A Sinflorio, Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Aline Cristina Abreu Moreira-Souza, Thuany Prado Rangel, Claudia L M Silva, Maria Bellio, Claudio Canetti, Robson Coutinho-Silva   +9 more
doaj   +1 more source

Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice

Journal of Nanobiotechnology
Background The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic effects, have been developed.
Catalina Abad, Mélanie Demeules, Charlotte Guillou, Henri Gondé, Rachid Zoubairi, Yossan-Var Tan, Carolina Pinto-Espinoza, Waldemar Schäfer, Anna Marei Mann, Valérie Vouret-Craviari, Friedrich Koch-Nolte, Sahil Adriouch   +11 more
doaj   +1 more source

P2X7 receptors and klotho [PDF]

Purinergic Signalling, 2020
openaire   +2 more sources

P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats

Scientific Reports
P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction.
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey   +9 more
doaj   +1 more source

Paradoxical P2X7 [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

P2X7 receptor [PDF]

Science-Business eXchange, 2009
openaire   +1 more source