Results 111 to 120 of about 67,493 (202)

The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35

Molecular Biology of the Cell, 2016
In a series of studies, we have identified TFP5, a truncated fragment of p35, the Cdk5 kinase regulatory protein, which inhibits Cdk5/p35 and the hyperactive Cdk5/p25 activities in test tube experiments. In cortical neurons, however, and in vivo in Alzheimer’s disease (AD) model mice, the peptide specifically inhibits the Cdk5/p25 complex and not the ...
Amin, Niranjana D., Zheng, Yali, BK, Binukumar, Shukla, Varsha, Skuntz, Susan, Grant, Philip, Steiner, Joseph, Bhaskar, Manju, Pant, Harish C.   +8 more
openaire   +2 more sources

PPSR1 Protein Functions as an Important Regulator to Enhance Plant Growth Performance Under N, P, and K Deficient Stress Conditions

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2385-2404, April 2026.
ABSTRACT Phosphorus (P) is an essential macronutrient for various biological processes in plant growth. Modern agricultural science has advanced the knowledge of regulatory mechanisms underlying phosphorus starvation responses (PSRs), aiming to develop phosphate‐efficient crops with sustainable production under reduced Pi fertilizer application ...
Jieyu Chen, Chuanhezi Quan, Yang Zhao, Imani L. D. S. Kalumith, Zhangjun Fei, Leon V. Kochian, William J. Lucas, Byung‐Kook Ham   +7 more
wiley   +1 more source

Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2014
About 15 years ago it was proposed that generation of the truncated protein p25 contributes to toxicity in Alzheimer's disease (AD). p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5).
Karl Peter eGiese
doaj   +1 more source

Double solids, categories and non-rationality

, 2013
This paper suggests a new approach to questions of rationality of threefolds based on category theory. Following M. Ballard, D. Favero, L. Katzarkov (ArXiv:1012.0864) and D. Favero, L.
Iliev, Atanas, Katzarkov, Ludmil, Przyjalkowski, Victor   +2 more
core   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Cloning, Expression and Characterization of Toxoplasma gondii P35 protein in E. coli [PDF]

Cell Journal, 2006
Introduction: Toxoplasma gondii is a protozoan parasite which is globallyprevalent in human and animals. Toxoplasma infection is commonlyasymptomatic, but can cause serious medical problems inimmunocompromised individuals and in fetus.
Parviz Kavakeb, Bahram Kazemi, Davood Dorostkar Moghaddam   +2 more
doaj  

CDK5: Key Regulator of Apoptosis and Cell Survival

Biomedicines, 2019
The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The activation of CDK5 is dependent on interaction with its activator p35,
Rabih Roufayel, Nimer Murshid
doaj   +1 more source

Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model

Journal of Ginseng Research, 2015
Background: Ginseng is known to have antiapoptotic, anti-inflammatory, and antioxidant effects. The present study investigated a possible role of Korean Red Ginseng (KRG) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in ...
Ye Lee Jun, Chang-Hwan Bae, Dongsoo Kim, Sungtae Koo, Seungtae Kim   +4 more
doaj   +1 more source

Dlùth is Inneach: Linguistic and Institutional Foundations for Gaelic Corpus Planning [PDF]

, 2014
This report presents the results of a one-year research project, commissioned by Bòrd na Gàidhlig BnG) and carried out by a Soillse Research team, whose goal was to answer the following question: What corpus planning principles are appropriate for the
Bell, Susan, McConville, Mark, McLeod, Wilson, Ó Maolalaigh, Roibeard   +3 more
core  

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease [PDF]

Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Du, L.P., He, H., Kijlstra, A., Lin, X.M., Yang, P.Z., Zhao, C.L., Zhou, H.Y.   +6 more
core   +2 more sources