Results 1 to 10 of about 327,693 (283)

5-fluorouracil suppresses stem cell-like properties by inhibiting p38 in pancreatic cancer cell line PANC-1

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: Suppressing the phenotype of cancer stem cells (CSCs) is a promising treatment strategy for cancer. P38 mitogen-activated protein kinases (MAPK, p38) play an important role in the occurrence, development, and stemness maintenance of tumors.
Jin Zhao, Xueying Shi, Changcheng Dong, Rui Liu, Lifu Su, Cuixia Cao   +5 more
doaj   +1 more source

Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa

Di-san junyi daxue xuebao, 2022
Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H.
YAN Zongbao, MAO Fangyuan, SHAN Zhiguo, ZHAO Yongliang, ZHUANG Yuan   +4 more
doaj   +1 more source

The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells [PDF]

Clinical and Experimental Otorhinolaryngology, 2011
ObjectivesDoxycycline is commonly used in medicine for its bacteriostatic antimicrobial properties. Recent studies have reported that doxycycline also has anti-inflammatory effects.
Chang Hoon Bae, Seung Min Chen, Heung-Man Lee, Si-Youn Song, Yong-Dae Kim   +4 more
doaj   +1 more source

Androgen receptor regulates the proliferation of myoblasts under appropriate or excessive stretch through IGF-1 receptor mediated p38 and ERK1/2 pathways

Nutrition & Metabolism, 2021
Background Androgen receptor (AR) exerts important roles in exercise-induced alterations of muscle mass, in which the proliferation and differentiation of satellite cells or myoblasts are crucial.
Shaoting Fu, Xiaojing Lin, Lijun Yin, Xiaohui Wang   +3 more
doaj   +1 more source

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source

Immunosuppressants Tacrolimus and Sirolimus revert the cardiac antifibrotic properties of p38-MAPK inhibition in 3D-multicellular human iPSC-heart organoids

Frontiers in Cell and Developmental Biology, 2022
Cardiac reactive fibrosis is a fibroblast-derived maladaptive process to tissue injury that exacerbates an uncontrolled deposition of large amounts of extracellular matrix (ECM) around cardiomyocytes and vascular cells, being recognized as a pathological
Yu Tian, Yu Tian, Yuta Tsujisaka, Yuta Tsujisaka, Vanessa Y. Li, Vanessa Y. Li, Kanae Tani, Kanae Tani, Antonio Lucena-Cacace, Yoshinori Yoshida   +9 more
doaj   +1 more source

Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization

Frontiers in Pharmacology, 2021
Myocardial fibrosis is closely related to high morbidity and mortality. In Inner Mongolia, Gentianella amarella subsp. acuta (Michx.) J.M.Gillett (G. acuta) is a kind of tea used to prevent cardiovascular diseases.
Hong-Xia Yang, Hong-Xia Yang, Jia-Huan Sun, Ting-Ting Yao, Yuan Li, Geng-Rui Xu, Chuang Zhang, Xing-Chao Liu, Wei-Wei Zhou, Qiu-Hang Song, Qiu-Hang Song, Qiu-Hang Song, Yue Zhang, Yue Zhang, Yue Zhang, Ai-Ying Li, Ai-Ying Li, Ai-Ying Li   +17 more
doaj   +1 more source

Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage

Particle and Fibre Toxicology, 2023
Background Polypropylene (PP) is used in various products such as disposable containers, spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly comprise PP, and the disposal of such masks is concerning because of the ...
Jong-Hwan Woo, Hyeon Jin Seo, Jun-Young Lee, Iljung Lee, Kisoo Jeon, Bumseok Kim, Kyuhong Lee   +6 more
doaj   +1 more source

ERK, p38 AND NF-kappaB SIGNALING IN MONOCYTE DERIVED DENDRITIC CELLS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME. [PDF]

Journal of IMAB, 2014
We have previously demonstrated that in patients with myelodysplastic syndrome (MDS) monocyte-derived DCs (MoDC) exhibit some phenotypic and functional abnormalities. However, the mechanisms underlying the defective response have not yet been clarified.
Ilina Micheva, Liana Gercheva, Panos Ziros, Nicholas Zoumbos   +3 more
doaj   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C., Bibby, Bo Martin, Funding, Anne, Iversen, Lars, Johansen, Claus, Kragballe, Knud, Lilleholt, Louise Langer   +6 more
core   +3 more sources