Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]
, 2014 BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L +3 more
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Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]
, 2006 BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore +7 more
core +3 more sources
DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]
, 2010 To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara +6 more
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Molecular mechanism of inhibition of 8-gingerol on proliferation of breast cancer cells
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of cell cycle on breast cancer cells by 8-gingerol. Methods The cell viability of breast cancer cells MDA-MB-231 and MCF-7 after treated by 8-gingerol at the doses of 0, 10, 20, 30 or 40 μmol/L for 24, 48 or 72 h was ...
YANG Chong, FU Ruoqiu, GAO Ning
doaj +1 more source
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. [PDF]
, 2015 Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling.
Aguilar, Berenice +7 more
core +2 more sources
LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling
Journal of Experimental & Clinical Cancer Research, 2019 Background The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is reported to be associated with multiple malignancies, but its role in the progression of pancreatic ductal adenocarcinoma (PDAC) remains to be determined.
Zhi-Bo Xie +4 more
doaj +1 more source
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes [PDF]
, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
A Diaz +52 more
core +5 more sources
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
Journal of Neuroinflammation, 2011 Background Neuropeptide Y (NPY) is emerging as a modulator of communication between the brain and the immune system. However, in spite of increasing evidence that supports a role for NPY in the modulation of microglial cell responses to inflammatory ...
Ferreira Raquel +6 more
doaj +1 more source
Peroxiredoxin 3 Inhibits Cardiac Fibrosis in Mice via NOX4-P38 Signalling [PDF]
Cell Journal, 2023 Objective: Peroxiredoxin-3 (Prx-3) is widely acknowledged as an antioxidant that protects against mitochondrialreactive oxygen species. Nonetheless, its role in cardiac fibrosis has not been elucidated. We aim to explore the roleand mechanism of Prx-3 in
Xiaoqi Xiong +9 more
doaj +1 more source
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]
, 2014 Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre +67 more
core +2 more sources