Results 51 to 60 of about 321,034 (216)
Advanced Healthcare Materials, EarlyView.Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han +10 more
wiley +1 more source
Neurobiology of Disease, 2008 We hypothesized that the brain-protective effect of hyperbaric oxygen (HBO) preconditioning in a transient global cerebral ischemia rat model is mediated by the inhibition of early apoptosis.One hundred ten male Sprague–Dawley (SD) rats (300–350 g body ...
Robert P. Ostrowski +8 more
doaj +1 more source
High glucose enhances lipopolysaccharide‐induced inflammation in cultured BV2 microglial cell line
Immunity, Inflammation and Disease, 2022 Introduction Diabetes mellitus emerges as a global health crisis and is related to the development of neurodegenerative diseases. Microglia, a population of macrophages‐like cells, govern immune defense in the central nervous system.
Hao‐Chang Hung +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach +7 more
wiley +1 more source
Biomolecules, 2021 Pirfenidone is a pyridinone derivative that has been shown to inhibit fibrosis in animal models and in patients with idiopathic pulmonary fibrosis. Its effect on orbital fibroblasts remains poorly understood.
Shi-Bei Wu +3 more
doaj +1 more source
Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2 [PDF]
, 2002 We reported previously that exogenously added human group V phospholipase A2 (hVPLA2) could elicit leukotriene B4 (LTB4) biosynthesis in human neutrophils (Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R., Wilton, D. C., Gelb, M.
Cho, Wonhwa +7 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise +4 more
wiley +1 more source
P38 kinase in gastrointestinal cancers
Cancer Gene Therapy, 2023 AbstractGastrointestinal cancers are a leading cause of cancer morbidity and mortality worldwide with 4.2 million new cases and 3.2 million deaths estimated in 2020. Despite the advances in primary and adjuvant therapies, patients still develop distant metastases and require novel therapies.
Thuy Phan +3 more
openaire +2 more sources
Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration
Advanced Materials Technologies, EarlyView.This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley +1 more source
Chinese Journal of Physiology, 2020 Toll-like receptor 4 (TLR-4), which regulate inflammatory reactions, has become a popular research topic in recent years. This article reviews the latest scientific evidence on the regulation of TLR-4 by regular aerobic exercise training.
Chien-Wei Chen +3 more
doaj +1 more source