Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways [PDF]
Open Medicine, 2023 Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)?
Peng Yiyan +5 more
doaj +4 more sources
Clinical Correlates Identify ProBDNF and Thrombo-Inflammatory Markers as Key Predictors of Circulating p75NTR Extracellular Domain Levels in Older Adults [PDF]
Frontiers in Aging Neuroscience, 2022 The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ...
Samuel Fleury +17 more
doaj +2 more sources
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression [PDF]
Frontiers in Cellular Neuroscience, 2019 Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75NTR has been identified as a positive modulator for Schwann
Nádia P. Gonçalves +13 more
doaj +2 more sources
p75NTR regulates postnatal skeletal development via NGF-responsive JNK signaling [PDF]
Bone Reportsp75NTR has emerged as a key regulator of skeletal development and bone homeostasis. To define its role, we characterized skeletal phenotypes in global and mesenchyme-specific p75NTR knockout mouse models.
Chiho Kadota-Watanabe +11 more
doaj +2 more sources
Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation [PDF]
BMC Oral HealthBackground The aim to this study was to explore the effect of p75NTR on the mineralization and development of maxillofacial processes. Moreover, we tried to elaborate the potential mechanism of p75NTR’s effect on the odontogenic or osteogenic ...
Feng Li +5 more
doaj +2 more sources
p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development [PDF]
Frontiers in Cell and Developmental BiologyCraniofacial abnormalities are among the most prevalent congenital defects, significantly affecting appearance, function, and quality of life. While the role of genetic mutations in craniofacial malformations is recognized, the underlying molecular ...
Byron Zhao +13 more
doaj +2 more sources
P75NTR activation limits CD21lo B cell subsets expansion in response to autoimmune-inducing challenges [PDF]
iScienceSummary: Studies, including our own, suggest that p75NTR plays a pivotal role in immune regulation. Here, we aimed to uncover the role of p75NTR signaling in regulating CD21lo B cell subsets, which are known to facilitate autoimmune activity, and to ...
Cong Luo +5 more
doaj +2 more sources
The p75NTR SIGNALING CASCADE MEDIATES MECHANICAL HYPERALGESIA INDUCED BY NERVE GROWTH FACTOR INJECTED INTO THE RAT HIND PAW [PDF]
, 2013 Nerve Growth Factor (NGF) augments excitability of isolated rat sensory neurons through activation of the p75 neurotrophin receptor (p75NTR) and its downstream sphingomyelin signaling cascade, wherein neutral sphingomyelinase(s) (nSMase), ceramide, and ...
Khodorova, Alla +2 more
core +3 more sources
Neurobiology of Disease, 2015 After nerve injury, Schwann cells (SCs) dedifferentiate, proliferate, and support axon regrowth. If axons fail to regenerate, denervated SCs eventually undergo apoptosis due, in part, to increased expression of the low-affinity neurotrophin receptor ...
Iram Ahmad +5 more
doaj +2 more sources
p75NTR alleviates diabetic periodontitis in mice by inhibiting inflammatory macrophage recruitment. [PDF]
BMC Oral HealthHuang Y +7 more
europepmc +2 more sources