Results 1 to 10 of about 10,177 (244)
The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells [PDF]
Cell Proliferation, 2020 AbstractObjectiveThe aim of this study is to investigate the role and potential mechanism of p75NTR in mineralization in vivo using p75NTR‐knockout mice and in vitro using ectomesenchymal stem cells (EMSCs).Materials and methodsFemur bone mass and daily incisor mineralization speed were assessed in an in vivo p75NTR‐knockout mouse model.
Manzhu Zhao +7 more
semanticscholar +5 more sources
p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development. [PDF]
Front Cell Dev BiolCraniofacial abnormalities are among the most prevalent congenital defects, significantly affecting appearance, function, and quality of life. While the role of genetic mutations in craniofacial malformations is recognized, the underlying molecular ...
Zhao B +11 more
europepmc +2 more sources
Clinical Correlates Identify ProBDNF and Thrombo-Inflammatory Markers as Key Predictors of Circulating p75NTR Extracellular Domain Levels in Older Adults [PDF]
Frontiers in Aging Neuroscience, 2022 The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ...
Samuel Fleury +17 more
doaj +2 more sources
Frontiers in Immunology, 2022 We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients.
Luciapia Farina +18 more
doaj +2 more sources
Nerve Growth Factor Receptor (NGFR/p75NTR) of the Small-Spotted Catshark (Scyliorhinus canicula): Evolutionary Conservation and Brain Function. [PDF]
J Comp Neurolp75NTR expression in the brain of the basal vertebrate Scyliorhinus canicula revealed its conservation across species. Functional conservation among vertebrates was demonstrated (i) by performing the canonical PC‐12 differentiation assay with the S. canicula NGF and (ii) by complementing the p75NTR absence in a PC‐12 p75NTR−/− knock‐out clone with the ...
Chiavacci E +5 more
europepmc +2 more sources
Journal of Immunology Research, 2021 Basal cell carcinoma (BCC) is the most common skin cancer. While most of the basal cell carcinomas were localized lesion and can be easily managed, the treatment options to the advanced basal cell carcinomas are still remarkably limited. In recent years,
Qingli Lu +3 more
doaj +2 more sources
Toluene Alters p75NTR Expression in the Rat Brainstem
INDUSTRIAL HEALTH, 2004 Toluene is a neurotoxic organic solvent widely used in industry. Acute toluene administration in rats induced a significant increase in the numbers of neural cells immunostained for p75NTR in several brainstem regions, such as the raphe magnus and the nucleus of the solitary tract, as well as in the lateral reticular, gigantocellular, vestibular and ...
Jesús Pascual +5 more
openalex +5 more sources
p75NTR: an enhancer of fenretinide toxicity in neuroblastoma [PDF]
Cancer Chemotherapy and Pharmacology, 2013 Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells.
Veena R. Ganeshan +2 more
openalex +5 more sources
p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation
eLife, 2022 Neuronal migration is one of the fundamental processes during brain development. Several neurodevelopmental disorders can be traced back to dysregulated migration.
Juan P Zanin, Wilma J Friedman
doaj +2 more sources
In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target
Trends in Pharmacological Sciences, 2021 The p75 neurotrophin receptor (p75NTR) functions at the molecular nexus of cell death, survival, and differentiation. In addition to its contribution to neurodegenerative diseases and nervous system injuries, recent studies have revealed unanticipated roles of p75NTR in liver repair, fibrinolysis, lung fibrosis, muscle regeneration, and metabolism ...
Christian Schachtrup +7 more
openaire +5 more sources