Results 21 to 30 of about 10,177 (244)
The expression system affects the binding affinity between p75NTR and proNGF. [PDF]
Biochem Biophys RepProNGF (nerve growth factor) is a precursor of NGF and a signaling peptide exerting opposite effects on neuronal cells, i.e., apoptotic or neuritogenic.
Hino M, Nakanishi M, Nomoto H.
europepmc +2 more sources
Frontiers in Molecular Neuroscience, 2018 The p75 neurotrophin receptor (p75NTR), also known as low-affinity nerve growth factor, belongs to the tumor necrosis factor family of receptors. p75NTR is widely expressed in the nervous system during the development, as well as, in the neural crest ...
Sabine Wislet +3 more
doaj +2 more sources
Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats. [PDF]
J Orthop Surg ResBackground Fractures heal through a process that involves angiogenesis and osteogenesis but may also lead to non-union or delayed healing. Bone marrow mesenchymal stem cells (BMSCs) have been reported to play a pivotal role in bone formation and vascular
Wu Z, Yang Y, Wang M.
europepmc +2 more sources
Cancer Research, 2018 Resistance to anoikis allows cancer cells to survive during systemic circulation; however, the mechanism underlying anoikis resistance remains unclear. Here we show that A disintegrin and metalloprotease 10 (ADAM10)-mediated cleavage of p75 neurotrophin ...
Xin Bao +7 more
openalex +2 more sources
A review of studies on the roles of p75NTR in the tooth development and tissue regeneration [PDF]
Yixue xinzhi zazhi, 2020 p75NTR, a low affinity neurotrophic factor receptor, is considered as a typical neural crest marker. It has been reported that p75NTR not only played an important role in the proliferation, migration, differentiation, survival and apoptosis of neural ...
Shi-Ting LI, Xia YU, Xiu-Jie WEN
doaj +1 more source
The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid ...
Francesco Bruno +5 more
semanticscholar +1 more source
eNeuro, 2023 Traumatic brain injury (TBI) elicits neuronal loss at the site of injury and progressive neuronal loss in the penumbra. However, the consequences of TBI on afferent neurons projecting to the injured tissue from distal locations is unknown.
Srestha Dasgupta +6 more
semanticscholar +1 more source
p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
Frontiers in Cell and Developmental Biology, 2023 The circadian clock plays a critical role in dentomaxillofacial development. Tooth biomineralization is characterized by the circadian clock; however, the mechanisms underlying the coordination of circadian rhythms with tooth development and ...
Bo Xie +10 more
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Glia, 2022 The disruption of the blood–brain barrier (BBB) plays a critical role in the pathology of ischemic stroke. p75 neurotrophin receptor (p75NTR) contributes to the disruption of the blood‐retinal barrier in retinal ischemia.
Xiaoying Qin +9 more
semanticscholar +1 more source
Open Medicine, 2023 Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)?
Peng Yiyan +5 more
doaj +1 more source